| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | BSTK3; CaMK1b |
| WB Predicted band size | 39 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human PNCK |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PNCK(Pregnancy Upregulated Nonubiquitous CaM Kinase)抗体的参考文献示例，基于公开研究整理：
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1. **文献名称**：*PNCK promotes cell proliferation and migration in breast cancer via calcium-mediated signaling*
**作者**：Smith A, et al.
**摘要**：本研究通过生成特异性PNCK多克隆抗体，验证其在乳腺癌细胞中的高表达，并发现PNCK通过钙信号通路促进肿瘤细胞增殖和迁移。抗体应用于Western blot和免疫荧光，证实其特异性。
2. **文献名称**：*Development of a monoclonal antibody against PNCK for immunohistochemical analysis in renal cell carcinoma*
**作者**：Lee J, Kim T.
**摘要**：研究团队开发了抗PNCK的单克隆抗体，用于检测肾癌组织中的蛋白表达。结果显示PNCK在肿瘤组织中的表达与患者预后相关，抗体在免疫组化中表现出高灵敏度和低交叉反应性。
3. **文献名称**：*PNCK modulates apoptosis resistance in ovarian cancer through ERK pathway activation*
**作者**：Chen L, et al.
**摘要**：通过siRNA敲低和抗PNCK抗体检测，研究发现PNCK通过激活ERK通路抑制卵巢癌细胞凋亡，提示其作为潜在治疗靶点。抗体用于流式细胞术和蛋白定位分析。
4. **文献名称**：*Characterization of PNCK expression in neurodegenerative models using a novel polyclonal antibody*
**作者**：Wang Y, et al.
**摘要**：该文献报道了一种新型PNCK多克隆抗体的开发，并验证其在阿尔茨海默病模型中的表达变化，表明PNCK可能参与神经退行性病变的钙稳态调控。
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**注**：以上文献为示例性内容，实际引用需以真实出版物为准。建议通过PubMed或Google Scholar以关键词“PNCK antibody”、“PNCK calcium kinase”检索最新研究。若需具体文献，可提供更详细的研究背景以便进一步筛选。
PNCK (Pregnancy Upregulated Nonubiquitous CaM Kinase), also known as CaMKIINα or CAMK1D, is a calcium/calmodulin-dependent serine/threonine kinase identified for its upregulated expression during pregnancy. First characterized in the late 1990s, PNCK belongs to the CaMK family and shares structural homology with other CaMK members, including a catalytic domain and regulatory regions responsive to calcium signaling. Unlike ubiquitous CaMK isoforms, PNCK exhibits tissue-specific expression, notably in reproductive organs, placenta, and certain cancers. Its function is linked to cell cycle regulation, apoptosis, and cellular stress responses, though its precise mechanisms remain under investigation.
Research highlights PNCK's dual role in physiological and pathological contexts. During pregnancy, it may contribute to placental development and maternal-fetal signaling. Conversely, aberrant PNCK expression correlates with tumor progression in breast, ovarian, and renal cancers, where it potentially modulates chemoresistance and metastasis. Antibodies against PNCK have become essential tools for detecting its expression and localization in tissues or cell lines via techniques like Western blot, immunohistochemistry, and immunofluorescence. These reagents aid in exploring PNCK's diagnostic or therapeutic potential, particularly in oncology. Commercial PNCK antibodies are typically validated for specificity across human, mouse, and rat homologs, supporting cross-species studies. Ongoing research seeks to clarify its signaling networks and clinical relevance.
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