| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | DJS; MRP2; cMRP; ABC30; CMOAT |
| WB Predicted band size | 174 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human ABCC2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于ABCC2抗体的参考文献及其摘要概括：
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1. **文献名称**: *Localization of MRP2 (ABCC2) in Human Liver and Kidney by Immunohistochemistry*
**作者**: Konig, J. et al.
**摘要**: 该研究利用特异性ABCC2抗体，通过免疫组化技术揭示了ABCC2蛋白在人类肝细胞胆管膜及肾近端小管上皮细胞的极性分布，证实其在胆红素和药物有机阴离子排泄中的关键作用。
2. **文献名称**: *ABCC2 Deficiency Confers Resistance to Chemotherapy in Hepatocellular Carcinoma*
**作者**: Chen, Z.S. et al.
**摘要**: 通过Western blot和免疫荧光技术，研究者发现ABCC2低表达的肝癌细胞对顺铂等化疗药物耐药性增强，提示ABCC2抗体可作为预测化疗反应的潜在生物标志物。
3. **文献名称**: *Mutation Analysis and Protein Localization of ABCC2 in Dubin-Johnson Syndrome*
**作者**: Paulusma, C.C. et al.
**摘要**: 该研究采用ABCC2抗体对Dubin-Johnson综合征患者肝组织进行分析，发现基因突变导致ABCC2蛋白表达缺失或异常定位，直接关联该疾病的先天性高胆红素血症表型。
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以上文献均通过ABCC2抗体揭示了该转运蛋白的生理功能及疾病关联，涵盖方法学验证、疾病机制及临床转化研究。如需更多文献，可进一步筛选特定研究方向(如药物代谢、癌症耐药性等)。
The ABCC2 antibody targets the ATP-binding cassette (ABC) transporter subfamily C member 2 (ABCC2), also known as Multidrug Resistance-Associated Protein 2 (MRP2). ABCC2 is a membrane-bound efflux transporter expressed predominantly in the liver, kidneys, and intestines. It plays a critical role in the excretion of organic anions, including conjugated bilirubin, glutathione, and drug metabolites, into bile or urine. ABCC2 dysfunction is linked to Dubin-Johnson syndrome, a hereditary disorder characterized by chronic conjugated hyperbilirubinemia. In cancer, ABCC2 overexpression is associated with multidrug resistance (MDR) by mediating the efflux of chemotherapeutic agents, reducing their intracellular efficacy.
The ABCC2 antibody is widely used in research to study the protein’s expression, localization, and function in normal physiology and disease. It is developed using immunogens such as recombinant ABCC2 protein fragments or synthetic peptides corresponding to specific epitopes, often validated in models like Western blotting, immunohistochemistry, or immunofluorescence. Researchers employ this antibody to investigate ABCC2's role in drug transport, detoxification pathways, and its impact on pharmacokinetics. Additionally, it aids in exploring mechanisms underlying liver/kidney diseases, drug-induced toxicity, and chemoresistance in oncology. Reliable ABCC2 antibodies are essential for advancing therapeutic strategies targeting ABC transporters.
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