Rabbit Polyclonal ADAP1 Antibody

The ADAP1 (ArfGAP with Dual PH Domains 1) antibody is a tool used to study the ADAP1 protein, which belongs to the ArfGAP (ADP-ribosylation factor GTPase-activating protein) family. ADAP1 regulates Arf proteins, small GTPases involved in membrane trafficking, cytoskeletal organization, and cellular signaling. Characterized by its dual pleckstrin homology (PH) domains, ADAP1 binds phosphoinositides, linking it to membrane-associated processes. It also contains a catalytic ArfGAP domain that accelerates GTP hydrolysis in Arf proteins, modulating their activity. ADAP1 is highly expressed in the brain, particularly in neurons, where it influences synaptic plasticity, neurite outgrowth, and receptor trafficking. Dysregulation of ADAP1 has been implicated in neurological disorders, including autism spectrum disorders and intellectual disabilities. Researchers use ADAP1 antibodies in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate its expression, localization, and interactions. These antibodies help elucidate ADAP1’s role in cellular pathways and disease mechanisms. Validation of antibody specificity is critical, as cross-reactivity with other ArfGAP family members can occur. Commercial ADAP1 antibodies are typically developed in hosts like rabbits or mice, targeting specific epitopes within the protein’s functional domains.