| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | ATR; TEM8 |
| WB Predicted band size | 63 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human ANTXR1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ANTXR1抗体的3篇参考文献摘要(信息基于公开文献概括，非真实引用，仅供参考)：
1. **文献名称**: "ANTXR1 as a Novel Biomarker in Triple-Negative Breast Cancer"
**作者**: Smith J, et al.
**摘要**: 研究发现ANTXR1在乳腺癌细胞中高表达，其抗体通过抑制肿瘤血管生成和细胞迁移，显著降低小鼠模型中肿瘤的生长和转移，提示其作为治疗靶点的潜力。
2. **文献名称**: "Structural Analysis of ANTXR1 Interaction with Pathogenic Toxins"
**作者**: Lee H, et al.
**摘要**: 利用ANTXR1特异性抗体解析了受体与炭疽毒素的结合表位，揭示了其跨膜结构域的关键作用，为抗毒素疗法开发提供了结构基础。
3. **文献名称**: "ANTXR1 Antibody-Mediated Targeting in Inflammatory Fibrosis"
**作者**: Zhang R, et al.
**摘要**: 研究证实ANTXR1在纤维化组织中异常激活，其抗体通过阻断TGF-β信号通路减轻小鼠肺纤维化病变，提示其在纤维化疾病中的治疗价值。
*注：以上为模拟示例，实际文献需通过PubMed/Google Scholar等平台检索。建议使用关键词“ANTXR1 antibody”、“TEM8 (肿瘤内皮标记8)”或“anthrax toxin receptor 1”查找具体研究。*
ANTXR1 (Anthrax Toxin Receptor 1), also known as Tumor Endothelial Marker 8 (TEM8), is a transmembrane protein initially identified for its role in binding anthrax toxin. It belongs to the integrin-like receptor family and interacts with the protective antigen (PA) component of anthrax toxin, facilitating toxin internalization. Beyond its link to anthrax infection, ANTXR1 is involved in physiological processes like extracellular matrix interaction, cell adhesion, and angiogenesis. Its expression is upregulated in certain cancers, contributing to tumor progression, metastasis, and vascular remodeling, making it a potential therapeutic target.
ANTXR1 antibodies are tools designed to detect or inhibit this receptor. These antibodies, often monoclonal or polyclonal, are used in research to study ANTXR1's expression, localization, and function in normal and pathological tissues. They are applied in techniques like Western blotting, immunohistochemistry (IHC), and flow cytometry. In therapeutic contexts, anti-ANTXR1 antibodies may block anthrax toxin entry or disrupt cancer-related signaling. Recent studies explore their utility in targeting tumor vasculature or delivering conjugated drugs. However, challenges remain in optimizing specificity and minimizing off-target effects. ANTXR1 antibodies thus serve as critical reagents in both mechanistic studies and translational applications, bridging infectious disease research and oncology.
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