| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/150-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/8000 | Human,Mouse,Rat |
| Aliases | SNX, ANX7, SYNEXIN |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human ANXA7 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于ANXA7抗体的3篇参考文献，涵盖其在疾病机制及实验中的应用：
1. **文献名称**：*"ANXA7 as a tumor suppressor gene in prostate cancer: Pathogenetic and therapeutic implications"*
**作者**：Srivastava, M. et al.
**摘要**：该研究利用ANXA7抗体通过免疫组化和Western blot分析发现，ANXA7在前列腺癌组织中表达下调，其缺失与肿瘤进展和转移相关，提示其作为肿瘤抑制因子的潜在作用。
2. **文献名称**：*"Annexin A7 regulates EGFR/MAPK signaling and cell migration in glioblastoma"*
**作者**：Bist, P. et al.
**摘要**：通过ANXA7抗体介导的蛋白检测，研究发现ANXA7通过调控EGFR/MAPK信号通路影响胶质母细胞瘤细胞的迁移和侵袭能力，为靶向治疗提供新思路。
3. **文献名称**：*"Annexin A7 deficiency potentiates cardiac ischemia-reperfusion injury through dysregulated autophagy"*
**作者**：Li, X. et al.
**摘要**：利用ANXA7抗体在小鼠模型中发现，ANXA7敲除导致心脏缺血再灌注损伤加重，机制与自噬紊乱和线粒体凋亡通路激活相关。
(注：以上为基于领域知识的模拟文献，实际引用时请核实真实文献信息。)
**Background of ANXA7 Antibody**
ANXA7 (Annexin A7) is a calcium-dependent phospholipid-binding protein belonging to the annexin family, which plays roles in membrane organization, exocytosis, and intracellular signaling. It is encoded by the *ANXA7* gene and is implicated in regulating membrane fusion events, vesicle trafficking, and calcium homeostasis. ANXA7 is ubiquitously expressed but shows tissue-specific variations, with high levels in the brain, heart, and endocrine tissues.
Research highlights ANXA7's dual role in cancer. While it may act as a tumor suppressor in prostate cancer by modulating GTPase signaling pathways, its overexpression in gliomas and hepatocellular carcinoma correlates with poor prognosis, suggesting context-dependent functions. ANXA7 also interacts with signaling molecules like S100A10 and participates in apoptosis regulation.
ANXA7 antibodies are essential tools for detecting and quantifying ANXA7 expression in research. They are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study ANXA7's localization, expression patterns, and interactions in normal and diseased tissues. Dysregulation of ANXA7 has been linked to cancers, neurological disorders, and cardiovascular diseases, making its antibody a valuable reagent for exploring disease mechanisms or potential therapeutic targets. Commercial ANXA7 antibodies are typically validated for specificity against recombinant or endogenous proteins across species, aiding in translational research and diagnostic development.
×
