关键信息
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基因名
PIGR
- 应用
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别名
PIGR; Polymeric immunoglobulin receptor; PIgR; Poly-Ig receptor) [Cleaved into: Secretory component]
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种属
Bovine
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P81265
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表达区间
400-599aa
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分子量
26.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
PIGR, or Polymeric Immunoglobulin Receptor, is a key protein involved in the transport of immunoglobulins across epithelial cells, facilitating the secretion of immune antibodies, particularly IgA, into mucosal surfaces. The significance of PIGR in immune responses, mucosal immunity, and pathogen defense has garnered attention in recent years, especially considering its potential impact on vaccine development and therapeutic interventions. Research has shown that PIGR plays a vital role in maintaining the balance of immune responses in various mucosal tissues, including the gut, respiratory tract, and salivary glands. Abnormalities in PIGR expression or function have been linked to several immunological disorders and infectious diseases, highlighting the need for a deeper understanding of this receptor. Additionally, recombinant PIGR (rPIGR) generated through biotechnology offers promising avenues for investigating its mechanisms and functions, paving the way for new strategies in immunotherapy and vaccine design. By studying rPIGR's interactions with different immunoglobulins and its role in epithelial transport, researchers aim to elucidate its involvement in mucosal immunity, which could lead to novel therapeutic applications in treating infections and enhancing immune responses. The ongoing research into rPIGR not only enhances our understanding of mucosal biology but also promises to bridge gaps in developing effective vaccines and immunomodulatory therapies, making it a focal point in molecular immunology and translational medicine efforts.
