Rabbit Polyclonal BAG1 Antibody

The BAG1 (Bcl-2-associated athanogene 1) antibody is a tool used to detect the BAG1 protein, a member of the BAG family of co-chaperones that regulates diverse cellular processes. BAG1 interacts with heat shock protein 70 (HSP70) and BCL-2. modulating protein folding, apoptosis, stress response, and proliferation. It exists in multiple isoforms (e.g., BAG1S, M, L) with distinct subcellular localizations, influencing its functional roles. In cancer research, BAG1 has dual implications: it may act as a tumor suppressor by enhancing apoptosis or as a pro-survival factor by stabilizing anti-apoptotic proteins, depending on context and isoform expression. Overexpression of BAG1 has been linked to poor prognosis in cancers like breast and thyroid, making its detection via antibodies valuable for prognostic studies and therapeutic targeting. BAG1 antibodies are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to assess protein expression patterns in tissues or cell lines. Beyond oncology, BAG1 is studied in neurodegenerative diseases (e.g., Alzheimer’s) and cardiac conditions due to its role in stress adaptation. Available as monoclonal or polyclonal variants, BAG1 antibodies require validation for specificity, as cross-reactivity with other BAG family members can occur. This antibody remains critical for unraveling BAG1’s complex roles in health and disease.