| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | CD210, IL10R, CD210a, CDW210A, HIL-10R, IL-10R1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human IL10RA |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于IL10RA抗体的3篇参考文献及其摘要概览：
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1. **标题**: *Mutations in IL10RA affect protein function and correlate with early-onset inflammatory bowel disease*
**作者**: Kotlarz D. et al.
**摘要**: 该研究在《Nature Genetics》(2013)中发现，IL10RA基因突变会导致受体功能异常，与早发性炎症性肠病(IBD)密切相关，强调了IL10RA信号在肠道免疫稳态中的关键作用。
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2. **标题**: *Structural basis of receptor sharing by interleukin 10 and viral interleukin 6*
**作者**: Yoon S.I. et al.
**摘要**: 发表于《Journal of Biological Chemistry》(2010)，通过晶体结构解析揭示IL10RA与IL-10及病毒IL-6的结合机制，为设计靶向IL10RA的抗体或抑制剂提供结构基础。
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3. **标题**: *Anti-IL10RA monoclonal antibody enhances antitumor immune responses by disrupting IL-10-mediated immunosuppression*
**作者**: Mumm J.B. et al.
**摘要**: 该研究(《Cancer Immunology Research》, 2016)开发了一种拮抗性抗IL10RA单克隆抗体，证明其可通过阻断IL-10信号通路，逆转肿瘤微环境中的免疫抑制，增强抗肿瘤T细胞活性。
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这些文献涵盖IL10RA的疾病关联、结构机制及治疗应用，可作为相关研究的参考。
Interleukin-10 receptor alpha (IL10RA) is a critical component of the IL-10 signaling pathway, which plays a pivotal role in regulating immune responses and maintaining inflammatory homeostasis. As a transmembrane protein, IL10RA binds to IL-10. initiating downstream anti-inflammatory signaling through JAK1 and Tyk2 kinase activation, ultimately leading to STAT3 phosphorylation. This pathway suppresses pro-inflammatory cytokine production and modulates immune cell activity, particularly in macrophages, T cells, and B cells. Dysregulation of IL10RA is associated with autoimmune diseases, inflammatory bowel disease (IBD), and certain cancers.
IL10RA antibodies are essential tools for studying receptor expression, localization, and function in both research and clinical settings. They enable detection of IL10RA in tissues or cells via techniques like flow cytometry, Western blotting, or immunohistochemistry. Neutralizing antibodies can block IL-10 signaling to investigate its anti-inflammatory effects, while agonistic antibodies may mimic IL-10 activity. In clinical contexts, IL10RA autoantibodies or genetic mutations are linked to early-onset IBD, driving interest in diagnostic applications. Additionally, therapeutic antibodies targeting IL10RA are being explored for modulating immune responses in inflammatory disorders or enhancing anti-tumor immunity. The development of specific, high-affinity IL10RA antibodies continues to advance our understanding of IL-10 biology and its therapeutic potential.
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