| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/500-1/10000 | Human,Mouse,Rat |
| WB Predicted band size | 51 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human BAG5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于BAG5抗体的3篇示例文献(注：文献为模拟生成，仅供参考)：
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1. **文献名称**：*BAG5 modulates proteostasis and regulates Aβ toxicity in Alzheimer's disease models*
**作者**：Smith J, et al.
**摘要**：本研究探讨了BAG5蛋白在阿尔茨海默病中的作用，利用特异性BAG5抗体检测其在神经元中的表达水平，发现BAG5通过调控自噬途径影响β-淀粉样蛋白(Aβ)的聚集，提示其作为治疗靶点的潜力。
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2. **文献名称**：*Development of a monoclonal antibody against human BAG5 for cancer biomarker studies*
**作者**：Li X, et al.
**摘要**：研究团队开发了一种高亲和力抗人BAG5单克隆抗体，并验证其在乳腺癌组织中的特异性识别能力。该抗体成功用于ELISA和免疫组化，显示BAG5在肿瘤微环境中过表达与患者预后不良相关。
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3. **文献名称**：*BAG5 interacts with Hsp70 to mitigate oxidative stress in Parkinson’s disease*
**作者**：Garcia R, et al.
**摘要**：通过免疫共沉淀(使用BAG5抗体)和体外实验，揭示了BAG5与Hsp70的相互作用在减轻多巴胺能神经元氧化损伤中的关键作用，为帕金森病的分子机制提供了新见解。
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如需具体文献，建议通过PubMed或Web of Science检索关键词“BAG5 antibody”或“BAG5 protein function”获取最新研究。
The BAG5 antibody is a research tool designed to detect and study the BAG5 protein, a member of the Bcl-2-associated athanogene (BAG) family. BAG proteins act as co-chaperones, modulating the activity of Hsc70/Hsp70 molecular chaperones through their conserved BAG domain. Unlike other BAG family members, BAG5 uniquely contains multiple BAG domains, suggesting distinct regulatory roles in protein folding, degradation, and stress response pathways. BAG5 is implicated in cellular processes such as apoptosis, autophagy, and protein quality control, with emerging links to neurodegenerative diseases. For instance, it interacts with Parkinson’s disease-associated proteins like LRRK2 and α-synuclein, potentially influencing disease mechanisms.
The BAG5 antibody enables researchers to investigate the protein’s expression, localization, and function in various tissues and disease models. It is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Studies employing this antibody have provided insights into BAG5’s dual roles—both protective and detrimental—in cellular stress responses, depending on context. Commercial BAG5 antibodies are available from multiple suppliers, often validated for specificity in human, mouse, or rat samples. However, variability in antibody performance across applications necessitates careful validation. Continued research using BAG5 antibodies may clarify its therapeutic potential in diseases such as Parkinson’s, cancer, and cardiac disorders.
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