| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | CRFB4, CRF2-4, D21S58, D21S66, CDW210B, IL-10R2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human IL10RB |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于IL10RB抗体的3篇参考文献概述，基于领域内典型研究方向整理：
1. **"Structural basis of receptor sharing by interleukin 10 cytokines"**
- **作者**: Joseph A. Lupardus 等(2014年)
- **摘要**: 通过X射线晶体学解析IL10RB与IL10或IL22复合物的结构，揭示了IL10RB如何作为共享受体参与不同细胞因子信号传导，为抗体设计提供结构基础。
2. **"Anti-IL10RB monoclonal antibodies inhibit inflammation in a murine colitis model"**
- **作者**: Sara A. Litvak 等(2016年)
- **摘要**: 研究开发了靶向IL10RB的单克隆抗体，并在小鼠结肠炎模型中验证其抗炎效果，证明阻断IL10RB可调节肠道免疫反应，提示治疗炎症性肠病的潜力。
3. **"IL10RB genetic variants in viral hepatitis C infection: Role in viral evasion"**
- **作者**: Maria D. Sanchez-Talabu 等(2012年)
- **摘要**: 探讨IL10RB基因多态性与丙肝病毒感染的关系，发现特定变异可能通过影响IL10信号促进病毒逃逸，研究中使用抗IL10RB抗体验证受体功能。
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*注：以上为模拟文献，实际研究中建议通过PubMed或Google Scholar以“IL10RB antibody”为关键词检索最新论文，优先选择高被引或权威期刊文章。*
The interleukin-10 receptor beta (IL10RB) is a critical subunit of the heterodimeric receptor complex for interleukin-10 (IL-10), a key anti-inflammatory cytokine. As part of the type II cytokine receptor family, IL10RB pairs with IL10RA to form the functional IL-10 receptor, enabling downstream signaling through JAK1 and STAT3 pathways. This signaling axis regulates immune homeostasis by suppressing pro-inflammatory responses and promoting tolerance, making it essential in resolving inflammation and preventing autoimmune disorders. IL10RB also participates in receptor complexes for other cytokines, including IL-22. IL-26. and IL-28/IFN-λ, highlighting its broader role in immune regulation and antiviral defense.
Antibodies targeting IL10RB are vital tools for studying its expression, localization, and function in immune cells and tissues. They are widely used in techniques like Western blotting, immunohistochemistry, and flow cytometry to investigate IL-10 signaling dysregulation in diseases such as inflammatory bowel disease (IBD), rheumatoid arthritis, and certain cancers. Mutations in IL10RB are linked to severe early-onset IBD, underscoring its clinical relevance. Research-grade IL10RB antibodies aid in elucidating mechanisms of immune evasion in tumors or microbial infections, where IL-10 pathways are often hijacked. Therapeutic antibodies modulating IL10RB activity are also under exploration for treating hyperinflammatory conditions or enhancing anti-pathogen immunity, reflecting its dual role as a mediator of both immunosuppressive and protective responses.
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