| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | K40; KA36; CK-40 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human KRT40 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是基于角蛋白抗体相关研究的常见方向整理的示例性参考文献框架(注：KRT40的研究较为少见，可能存在名称准确性或文献稀缺问题，建议进一步核实信息或调整关键词)：
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1. **标题**: "Characterization of Keratin 40 Expression in Human Intestinal Epithelium"
**作者**: Smith A, et al.
**摘要**: 本研究首次报道了KRT40蛋白在人肠道上皮细胞中的特异性表达，并开发了兔源多克隆抗体。通过免疫组化和Western blot验证了抗体的特异性，发现KRT40可能与肠道屏障功能相关。
2. **标题**: "Development of a Monoclonal Antibody for Keratin 40 and Its Application in Cancer Diagnostics"
**作者**: Zhang L, et al.
**摘要**: 文章描述了一种新型小鼠抗人KRT40单克隆抗体的制备，该抗体在结直肠癌组织样本中显示出高亲和力，提示KRT40可能作为肿瘤标志物的潜在价值。
3. **标题**: "Keratin 40 in Epidermal Differentiation: Insights from Knockout Mouse Models"
**作者**: Brown K, et al.
**摘要**: 利用KRT40基因敲除小鼠模型，结合特异性抗体分析，揭示了KRT40在皮肤表皮分化中的作用，并发现其缺失导致角质层结构异常。
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**注意**：上述文献为示例性内容，实际研究中KRT40的相关报道较少，可能存在以下问题：
- **名称准确性**：请确认目标蛋白是否为KRT40(人类基因组中KRT40基因存在，但研究较少)，或是否可能为其他角蛋白(如KRT14、KRT19等)。
- **检索建议**：推荐使用PubMed或Google Scholar，以“KRT40 antibody”、“Keratin 40”等关键词搜索最新文献，或查阅抗体公司(如Abcam、Sigma)的产品引用文献。
- **替代方案**：若需实际引用，可考虑扩大范围至“角蛋白家族抗体”或“细胞骨架标记物”相关研究。
The KRT40 antibody targets keratin 40 (KRT40), a member of the keratin family of intermediate filament proteins crucial for maintaining structural integrity in epithelial and hair follicle cells. Keratins are categorized into type I (acidic) and type II (basic), forming heteropolymers that provide mechanical stability to cells. While KRT40 is less characterized compared to other keratins like KRT5 or KRT14. it is implicated in specialized epithelial structures, including hair and nails. Its expression may vary across tissues, suggesting roles in tissue-specific differentiation or stress response.
Antibodies against KRT40 are primarily used in research to study epithelial biology, hair follicle development, and keratin-related disorders. They enable detection via techniques such as immunohistochemistry (IHC), immunofluorescence (IF), and Western blotting. In clinical contexts, abnormal keratin expression is linked to diseases like epidermolysis bullosa or certain carcinomas, making KRT40 a potential biomarker. However, limited studies on KRT40 necessitate cautious interpretation, emphasizing the need for antibody validation using controls like knockout models or siRNA. Commercial KRT40 antibodies are available but vary in specificity, highlighting the importance of rigorous optimization for experimental accuracy. Ongoing research aims to clarify KRT40's functional significance and therapeutic relevance.
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