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Rabbit Polyclonal CAPN7 Antibody

  • 中文名: CAPN7抗体
  • 别    名: PALBH; CALPAIN7
货号: IPDX07145
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/2000-1/5000 Human,Mouse,Rat

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参考文献

以下是关于CAPN7抗体的模拟参考文献示例(请注意,以下内容为虚构,实际文献需通过学术数据库查询验证):

1. **文献名称**:*Characterization of CAPN7-specific antibodies and their role in autophagy regulation*

**作者**:Saito, M. et al.

**摘要**:本研究开发了一种高特异性CAPN7抗体,并验证其在人细胞系中的表达。通过免疫印迹和免疫荧光实验,发现CAPN7在自噬过程中与溶酶体膜蛋白相互作用,提示其可能参与自噬调控通路。

2. **文献名称**:*CAPN7 expression profiling in gastric cancer using a novel monoclonal antibody*

**作者**:Zhang, L. et al.

**摘要**:报道了一种新型CAPN7单克隆抗体的制备,并利用该抗体分析胃癌组织中CAPN7的表达水平。结果显示,CAPN7在肿瘤组织中的表达显著上调,可能与患者预后不良相关。

3. **文献名称**:*Functional analysis of CAPN7 in neuronal cells via antibody-mediated knockdown*

**作者**:Gupta, R. et al.

**摘要**:利用CAPN7特异性抗体进行功能阻断实验,发现抑制CAPN7活性可导致神经元细胞轴突生长异常,表明其在神经发育中可能发挥关键作用。

4. **文献名称**:*CAPN7 antibody reveals subcellular localization and protease activity in mitochondrial-associated membranes*

**作者**:Park, J. & Lee, S.

**摘要**:通过CAPN7抗体的免疫电镜分析,发现CAPN7主要定位于线粒体相关膜结构(MAM),并证实其钙依赖性蛋白酶活性对线粒体功能具有调控作用。

**提示**:以上为示例性内容,实际文献需通过PubMed、Web of Science等平台检索。建议结合“CAPN7 antibody”、“calpain 7”等关键词进行精准查询。

背景信息

The CAPN7 antibody targets calpain-7 (CAPN7), a member of the calcium-dependent cysteine protease family, though its proteolytic activity remains less characterized compared to classical calpains. CAPN7. also known as paladin, is distinguished by its unique domain structure, featuring three N-terminal C2 domains and a C-terminal protease-like domain lacking critical catalytic residues, suggesting non-enzymatic roles. It is implicated in membrane trafficking, endocytosis, and lysosomal function, particularly through interactions with the endosomal sorting complex required for transport (ESCRT) machinery. Studies link CAPN7 to neural development, autophagy, and cancer progression, with altered expression observed in gliomas and breast cancers. The CAPN7 antibody is a critical tool for detecting the protein's expression, localization, and interaction partners in cellular and tissue contexts. Validated applications include Western blotting, immunofluorescence, and immunoprecipitation, aiding research into its regulatory mechanisms in vesicle dynamics and disease pathways. However, specificity validation is essential due to potential cross-reactivity with structurally similar proteins. Ongoing research aims to clarify CAPN7's precise biological functions and therapeutic relevance.

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