| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | CAXiV |
| WB Predicted band size | 38 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human CA14 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CA14抗体的3篇文献示例(内容为模拟概括，仅供参考)：
1. **《Carbonic Anhydrase XIV as a Biomarker in Glioblastoma》**
- **作者**: Smith A, et al. (2020)
- **摘要**: 研究利用CA14特异性抗体通过免疫组化分析脑胶质瘤组织，发现CA14高表达与肿瘤侵袭性相关，提示其可作为潜在治疗靶点。
2. **《Immunolocalization of CA14 in the Retinal Pigment Epithelium》**
- **作者**: Johnson B, et al. (2018)
- **摘要**: 通过CA14抗体的免疫荧光染色，揭示CA14在小鼠视网膜色素上皮细胞中的特异性表达，推测其在维持视网膜pH稳态中起关键作用。
3. **《Development of a Novel CA14 Monoclonal Antibody for Diagnostic Applications》**
- **作者**: Lee C, et al. (2021)
- **摘要**: 报道一种高亲和力CA14单克隆抗体的开发，验证其在ELISA和Western blot中的特异性，为卵巢癌早期诊断提供新工具。
4. **《Structural Insights into CA14 via Antibody-Epitope Mapping》**
- **作者**: Zhang Y, et al. (2019)
- **摘要**: 结合CA14抗体表位定位和晶体学分析，揭示CA14的胞外结构域构象，为设计靶向抑制剂奠定基础。
(注：以上文献信息为示例，实际引用需查询真实数据库如PubMed或Web of Science。)
**Background of CA14 Antibody**
The CA14 antibody targets carbonic anhydrase XIV (CA XIV), a member of the carbonic anhydrase (CA) family, which are zinc-containing metalloenzymes that catalyze the reversible hydration of carbon dioxide. CA XIV, encoded by the *CA14* gene, was identified in the early 2000s as a transmembrane isoform expressed in specific tissues, including the kidney, central nervous system, retina, and skeletal muscle. It plays a role in pH regulation, ion transport, and cellular signaling, particularly in tissues requiring rapid acid-base balance.
CA XIV is anchored to the cell membrane via a glycosylphosphatidylinositol (GPI) linkage, distinguishing it from other membrane-associated CAs. Studies suggest its involvement in retinal function, neuronal excitability, and renal bicarbonate reabsorption. Dysregulation of CA XIV has been loosely linked to pathological conditions, such as retinal disorders, epilepsy, and certain cancers, though its precise mechanisms remain under investigation.
The CA14 antibody is a crucial tool for detecting CA XIV expression and localization in research settings. It enables studies using techniques like immunohistochemistry, Western blotting, and immunofluorescence to explore CA XIV's physiological roles and potential as a therapeutic target. Despite its emerging significance, CA XIV remains less characterized compared to other CA isoforms (e.g., CA IX or CA XII), highlighting the need for further research to elucidate its contributions to health and disease.
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