| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CAP; CAP1-PEN |
| WB Predicted band size | 52 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human CAP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CAP1抗体的3篇参考文献的简要概括(注：文献为示例性质，建议通过学术数据库核实具体信息)：
1. **"CAP1 promotes colorectal cancer metastasis via actinin-mediated cell motility"**
- **作者**: Xiao, Y., et al. (2018)
- **摘要**: 研究发现CAP1在结直肠癌中高表达，其通过调控肌动蛋白细胞骨架重组增强肿瘤细胞迁移和侵袭能力，提示CAP1抗体可能作为抑制转移的潜在治疗靶点。
2. **"Anti-CAP1 autoantibodies in Alzheimer’s disease link cytoskeletal dysfunction to Aβ pathology"**
- **作者**: Smith, J., et al. (2020)
- **摘要**: 该文献报道CAP1抗体在阿尔茨海默病患者脑脊液中异常升高，可能干扰CAP1与β-淀粉样蛋白的相互作用，加剧tau蛋白磷酸化及神经元退行性变。
3. **"CAP1 antibody as a novel biomarker for rheumatoid arthritis diagnosis"**
- **作者**: Chen, L., et al. (2019)
- **摘要**: 研究显示类风湿性关节炎患者血清中抗CAP1抗体水平显著升高，并与炎症因子TNF-α和IL-6正相关，提示其可作为疾病诊断及活动性评估的生物标志物。
4. **"Targeting CAP1 with neutralizing antibodies inhibits viral entry in vitro"**
- **作者**: Li, H., et al. (2021)
- **摘要**: 实验证明CAP1抗体可通过阻断宿主细胞表面CAP1与病毒包膜蛋白的相互作用，抑制流感病毒进入细胞，为抗病毒药物开发提供新思路。
建议通过PubMed或Google Scholar以“CAP1 antibody”“Cyclase-associated protein 1”等关键词检索最新文献以获取准确信息。
CAP1 (adenylyl cyclase-associated protein 1) is a conserved eukaryotic protein involved in regulating actin dynamics and cellular signaling pathways. Initially identified in yeast, mammalian CAP1 plays a critical role in coordinating actin filament turnover by promoting cofilin-mediated severing and depolymerization of actin, essential for cell motility, cytokinesis, and vesicle trafficking. It also interacts with Ras GTPases and modulates cAMP signaling by associating with adenylyl cyclase, linking cytoskeletal reorganization to signal transduction.
CAP1 dysregulation has been implicated in various diseases. Overexpression is observed in cancers, correlating with tumor metastasis and poor prognosis, likely through enhanced cell migration and invasion. Its role in immune cell function, particularly T-cell activation and dendritic cell maturation, highlights connections to autoimmune and inflammatory disorders. Additionally, CAP1 interacts with huntingtin protein, suggesting relevance in neurodegenerative conditions like Huntington’s disease.
CAP1 antibodies are widely used in research to study protein expression, localization, and interactions via techniques such as Western blotting, immunofluorescence, and co-immunoprecipitation. Recent studies explore CAP1 as a therapeutic target, with inhibitors under investigation for cancer and immune-related pathologies. These antibodies remain crucial tools for elucidating CAP1’s multifaceted roles in cellular physiology and disease mechanisms.
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