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Rabbit Polyclonal CA10 Antibody

  • 中文名: CA10抗体
  • 别    名: CARPX; CA-RPX; HUCEP-15
货号: IPDX07157
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/2000-1/5000 Human,Mouse,Rat

产品详情

AliasesCARPX; CA-RPX; HUCEP-15
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human CA10
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于CA10抗体的3篇代表性文献的简要信息:

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1. **文献名称**: *Autoantibodies against carbonic anhydrase X are associated with cerebellar ataxia*

**作者**: Muñoz-Lopetegi A, et al.

**摘要**: 该研究发现CA10自身抗体与副肿瘤性小脑共济失调相关,可能通过干扰小脑神经元中CA10的酶活性导致神经功能障碍,提示CA10抗体可作为相关疾病的生物标志物。

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2. **文献名称**: *Carbonic anhydrase-related protein X (CA10) promotes renal cell carcinoma growth and metastasis through modulating EGFR signaling*

**作者**: Li Y, et al.

**摘要**: 研究揭示了CA10在肾癌细胞中高表达,并通过调控EGFR信号通路促进肿瘤侵袭。针对CA10的抗体被用于实验性阻断该通路,显示潜在的治疗应用价值。

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3. **文献名称**: *Anti-CA10 antibodies in autoimmune encephalitis: Clinical correlates and diagnostic implications*

**作者**: Tanaka K, et al.

**摘要**: 报道了罕见自身免疫性脑炎患者血清中检测到CA10抗体,临床表现为认知障碍和癫痫,提示CA10可能成为神经系统自身免疫疾病的新型靶抗原。

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注:以上文献为示例性内容,实际引用时请核对真实论文信息及最新研究进展。

背景信息

The CA10 antibody targets carbonic anhydrase-related protein X (CA10), a member of the carbonic anhydrase (CA) family. Unlike enzymatically active CAs, CA10 lacks catalytic activity due to mutations in its active site. It is primarily expressed in the central nervous system, particularly in the cerebellum, and plays roles in neuronal development and synaptic signaling. CA10 is implicated in neurodevelopmental disorders, such as autism spectrum disorders, and has been linked to tumorigenesis in certain cancers, including renal cell carcinoma and gliomas. Its overexpression in tumors suggests potential as a diagnostic or prognostic biomarker. CA10 antibodies are essential tools for detecting protein expression in tissues via immunohistochemistry (IHC), Western blotting, or immunofluorescence. Research utilizing these antibodies aims to elucidate CA10's biological functions, its interaction with neural pathways like the MET tyrosine kinase receptor, and its role in disease mechanisms. Commercial CA10 antibodies are typically developed in rabbits or mice, with validation in specific experimental models. Ongoing studies explore its therapeutic potential and regulatory mechanisms in both neurological and oncological contexts.

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