| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | CKII; CK2A1; CSNK2A3 |
| WB Predicted band size | 45 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human CSNK2A1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CSNK2A1抗体的3篇参考文献示例(文献信息为模拟内容，仅供格式参考)：
1. **文献名称**：*Casein Kinase 2 Alpha 1 (CSNK2A1) is a critical regulator of colorectal cancer cell proliferation*
**作者**：Smith J, et al.
**摘要**：该研究通过Western blot和免疫组化技术，使用CSNK2A1抗体验证了其在结直肠癌组织中的过表达，并发现其通过调控Wnt/β-catenin通路促进肿瘤生长。
2. **文献名称**：*CSNK2A1-mediated phosphorylation stabilizes oncogenic proteins in leukemia*
**作者**：Lee H, et al.
**摘要**：研究利用CSNK2A1抗体进行免疫共沉淀实验，揭示了该激酶通过磷酸化作用维持白血病细胞中关键致癌蛋白的稳定性，抑制其降解。
3. **文献名称**：*Inhibition of CSNK2A1 enhances sensitivity to chemotherapy in breast cancer models*
**作者**：Wang Y, et al.
**摘要**：通过siRNA敲低CSNK2A1并结合抗体检测蛋白表达，研究发现靶向该激酶可增强乳腺癌细胞对化疗药物的敏感性，机制与凋亡通路激活相关。
4. **文献名称**：*CSNK2A1 antibody-based profiling reveals its role in neurodegenerative tauopathies*
**作者**：Garcia R, et al.
**摘要**：利用特异性CSNK2A1抗体分析阿尔茨海默病模型，发现该激酶异常激活导致tau蛋白过度磷酸化，与神经退行性病变密切相关。
(注：以上文献为示例，实际引用需查询真实数据库如PubMed、Google Scholar等。)
The CSNK2A1 antibody targets the alpha 1 catalytic subunit of Casein Kinase 2 (CK2), a ubiquitously expressed serine/threonine kinase involved in critical cellular processes, including proliferation, apoptosis, DNA repair, and signal transduction. CK2 exists as a heterotetrameric complex, typically composed of two catalytic subunits (α/α') and two regulatory β subunits. CSNK2A1 encodes the α subunit, which drives the kinase's enzymatic activity by phosphorylating diverse substrates, such as transcription factors, tumor suppressors, and signaling proteins. Dysregulation of CK2. particularly CSNK2A1 overexpression, is linked to cancer progression, neurodegenerative disorders, and inflammatory diseases, making it a potential therapeutic target.
Antibodies against CSNK2A1 are essential tools for studying its expression, localization, and function in normal and pathological contexts. They are widely used in techniques like Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF) to quantify protein levels, assess tissue-specific distribution, or investigate signaling pathways. Monoclonal and polyclonal variants exist, with validation depending on applications (e.g., specificity in knock-out models or cross-reactivity checks). Researchers also utilize these antibodies to explore CK2's role in modulating pathways like Wnt, NF-κB, and PI3K/Akt, providing insights into disease mechanisms and drug discovery. Reliable CSNK2A1 antibodies are critical for both basic research and translational studies aiming to target CK2 in precision medicine.
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