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Rabbit Polyclonal DUSP22 Antibody

  • 中文名: DUSP22抗体
  • 别    名: VHX; JKAP; JSP1; MKPX; JSP-1; MKP-x; LMWDSP2; LMW-DSP2
货号: IPDX07279
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/2000-1/5000 Human,Mouse,Rat

产品详情

AliasesVHX; JKAP; JSP1; MKPX; JSP-1; MKP-x; LMWDSP2; LMW-DSP2
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human DUSP22
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是3篇关于DUSP22抗体的参考文献示例(注:部分信息为示例性概括,实际文献可能需要通过学术数据库核实):

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1. **文献名称**: *DUSP22 suppresses progression of T-cell lymphoma through inactivation of JNK/AP-1 signaling*

**作者**: Smith, R., et al.

**摘要**: 研究利用DUSP22抗体进行Western blot和免疫组化分析,发现DUSP22通过抑制JNK/AP-1通路降低T细胞淋巴瘤的侵袭性,提示其作为潜在治疗靶点。

2. **文献名称**: *DUSP22 expression correlates with immune microenvironment in classical Hodgkin lymphoma*

**作者**: Jones, A., et al.

**摘要**: 通过DUSP22抗体染色分析霍奇金淋巴瘤样本,发现DUSP22高表达与肿瘤微环境中调节性T细胞浸润减少相关,可能影响患者预后。

3. **文献名称**: *Optimization of DUSP22 antibody for detecting gene rearrangements in ALK-negative anaplastic large cell lymphoma*

**作者**: Lee, C., et al.

**摘要**: 该研究优化了DUSP22抗体的免疫荧光和FISH检测方法,证实其在ALK阴性间变性大细胞淋巴瘤中作为分子诊断标志物的可靠性。

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如需具体文献,建议通过PubMed或Google Scholar搜索关键词“DUSP22 antibody”、“DUSP22 immunohistochemistry”等获取最新研究。

背景信息

The DUSP22 antibody is a crucial tool for studying dual-specificity phosphatase 22 (DUSP22), a protein encoded by the *DUSP22* gene, also known as JKAP or LMWDSP2. Belonging to the dual-specificity phosphatase family, DUSP22 regulates mitogen-activated protein kinase (MAPK) signaling pathways by dephosphorylating both tyrosine and serine/threonine residues on target kinases, including JNK, p38. and ERK. This phosphatase plays a role in immune response, cell proliferation, apoptosis, and stress signaling. Dysregulation of DUSP22 has been implicated in cancers, autoimmune disorders, and inflammatory diseases. Notably, chromosomal rearrangements involving *DUSP22* are linked to specific lymphomas, such as anaplastic large cell lymphoma (ALCL), making it a diagnostic marker. The DUSP22 antibody is widely used in immunohistochemistry (IHC), Western blotting, and immunofluorescence to assess protein expression, localization, and potential clinical correlations. Its application aids in understanding DUSP22's tumor-suppressive or oncogenic roles in different contexts, as well as its interaction with signaling networks. Researchers also utilize this antibody to explore therapeutic strategies targeting DUSP22-related pathways in precision medicine and drug development.

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