Rabbit Polyclonal DUSP13 Antibody

The DUSP13 antibody is a research tool designed to detect and study dual-specificity phosphatase 13 (DUSP13), a member of the dual-specificity phosphatase family. DUSP13. also known as TESK2 (testis-specific kinase 2) cofactor or MDSP (muscle-restricted DUSP), regulates mitogen-activated protein kinase (MAPK) signaling pathways by dephosphorylating both tyrosine and serine/threonine residues on target kinases. This enzyme is implicated in cellular processes such as proliferation, differentiation, and stress responses. DUSP13 exists in two splice variants, DUSP13A (expressed in testis and skeletal muscle) and DUSP13B (predominantly in the heart), with distinct tissue-specific roles. Antibodies targeting DUSP13 are used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore its expression patterns, subcellular localization, and interactions in physiological or pathological contexts. Research has linked DUSP13 to muscle development, cancer progression (e.g., modulating ERK/JNK pathways), and metabolic disorders, making its antibody valuable for mechanistic studies. Validation of specificity (via knockout controls) and cross-reactivity assessments are critical due to homology within the DUSP family. These antibodies aid in uncovering DUSP13's regulatory roles in signaling networks and its potential as a therapeutic target.