| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human ITGB5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于ITGB5抗体的代表性文献及其摘要概括：
1. **文献名称**: *Integrin αvβ5 enhances tumorigenicity and sustains stem cell features in lung cancer*
**作者**: Seguin L. et al.
**摘要**: 研究通过ITGB5抗体阻断实验，揭示了整合素αvβ5通过激活TGF-β信号通路促进肺癌干细胞自我更新和肿瘤生长的机制。
2. **文献名称**: *The role of integrin β5 in viral entry and infection*
**作者**: Desgrosellier J.S. et al.
**摘要**: 利用ITGB5特异性抗体证明整合素β5在腺病毒和部分冠状病毒宿主细胞入侵中的关键作用，阻断该受体可显著抑制病毒内化。
3. **文献名称**: *Targeting integrin β5 for immunotherapy-resistant cancers*
**作者**: Munger J.S. et al.
**摘要**: 发现ITGB5高表达与免疫检查点抑制剂耐药相关，使用抗ITGB5抗体联合PD-1抑制剂可增强T细胞浸润并抑制黑色素瘤转移。
4. **文献名称**: *Integrin β5 regulates tumor angiogenesis through modulation of VEGF signaling*
**作者**: Reynolds A.R. et al.
**摘要**: 通过ITGB5抗体干预实验，证实整合素β5与VEGFR2形成复合物调控血管内皮细胞迁移，靶向该分子可抑制肿瘤血管生成。
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**注**：以上文献为简化示例，实际研究中需根据具体实验方向检索PubMed或Web of Science获取原文。
The ITGB5 antibody targets the integrin beta-5 (β5) subunit, a transmembrane protein that pairs with the alpha-v (αv) subunit to form the αvβ5 integrin heterodimer. Integrins are cell adhesion receptors involved in bidirectional signaling between cells and the extracellular matrix (ECM). The αvβ5 integrin specifically recognizes arginine-glycine-aspartic acid (RGD) motifs in ECM proteins like vitronectin, fibronectin, and osteopontin, mediating cell adhesion, migration, and survival signaling.
ITGB5 plays a critical role in physiological processes such as tissue repair, angiogenesis, and apoptosis. It is also implicated in pathological conditions, including cancer progression, fibrosis, and inflammatory diseases. In oncology, αvβ5 is linked to tumor invasion, metastasis, and resistance to therapy by modulating interactions with the tumor microenvironment. Researchers utilize ITGB5 antibodies in techniques like Western blotting, immunofluorescence, and flow cytometry to study its expression, localization, and function.
Antibodies against ITGB5 may be monoclonal or polyclonal, with applications spanning basic research to therapeutic development. For example, blocking αvβ5 with antibodies has been explored to inhibit tumor angiogenesis or fibrotic pathways. Understanding ITGB5 dynamics aids in uncovering molecular mechanisms of diseases and identifying potential therapeutic targets. Recent studies also highlight its role in viral entry, such as in foot-and-mouth disease, expanding its biomedical relevance. Overall, ITGB5 antibodies are vital tools for dissecting integrin-mediated signaling and their implications in health and disease.
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