| WB | 1/200-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | AIP70; SIMPL |
| WB Predicted band size | 29 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human IRAK1BP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于IRAK1BP1抗体的3篇参考文献示例(注：文献为模拟示例，实际引用需核实)：
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1. **Title**: IRAK1BP1 regulates TLR-induced NF-κB activation by targeting IKK complexes
**Author**: Smith J, et al.
**Summary**: 本研究利用IRAK1BP1特异性抗体，通过免疫共沉淀(Co-IP)和Western blot技术，发现IRAK1BP1通过结合IKKγ(NEMO)抑制TLR信号通路中NF-κB的过度激活，揭示了其在炎症反应中的负调控机制。
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2. **Title**: Autophagy-dependent degradation of IRAK1BP1 modulates inflammatory responses
**Author**: Chen L, et al.
**Summary**: 通过免疫荧光和流式细胞术结合IRAK1BP1抗体，作者证实IRAK1BP1在巨噬细胞自噬过程中被选择性降解，其稳定性丧失导致IL-1β分泌增加，提示其通过自噬-炎症串扰调控先天免疫。
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3. **Title**: IRAK1BP1 antibody-based screening identifies its overexpression in rheumatoid arthritis
**Author**: Wang Y, et al.
**Summary**: 研究采用IRAK1BP1抗体对类风湿关节炎患者滑膜组织进行免疫组化分析，发现IRAK1BP1蛋白水平与疾病严重程度呈负相关，提示其可能作为炎症性关节病的潜在生物标志物。
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如需实际文献，建议在PubMed等数据库中检索关键词：**IRAK1BP1 antibody** 或 **IRAK1BP1 function**，并筛选涉及抗体应用的研究。
The IRAK1BP1 (Interleukin-1 Receptor-Associated Kinase 1 Binding Protein 1) antibody is a tool used to detect and study the IRAK1BP1 protein, which plays a regulatory role in innate immune signaling pathways. IRAK1BP1. also known as SIMPL (STAT-interacting MAPK pathway-associated protein), interacts with components of the interleukin-1 receptor (IL-1R) and Toll-like receptor (TLR) signaling cascades, particularly modulating NF-κB activation. It acts as a negative regulator, fine-tuning inflammatory responses by inhibiting IRAK1-dependent signaling, thus influencing cytokine production and immune homeostasis.
Antibodies targeting IRAK1BP1 are widely utilized in research to investigate its expression, localization, and function in immune cells and disease models. These antibodies are commonly validated for applications like Western blotting, immunoprecipitation, immunofluorescence, and immunohistochemistry. Studies employing IRAK1BP1 antibodies have linked the protein to autoimmune diseases, chronic inflammation, and cancer, where dysregulated NF-κB signaling is often implicated. For instance, reduced IRAK1BP1 expression has been observed in certain cancers, suggesting its potential role as a tumor suppressor. Researchers also explore its involvement in crosstalk between innate immunity and other pathways, such as autophagy or apoptosis. The development of specific, high-affinity IRAK1BP1 antibodies has been critical in elucidating its molecular interactions and therapeutic relevance.
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