| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/5-1/20 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human HDC |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于HDC(组氨酸脱羧酶)抗体的参考文献摘要示例：
1. **《Histidine Decarboxylase Expression in Human Mast Cell Disorders》**
- 作者：Smith A. et al. (2020)
- 摘要：研究利用特异性HDC抗体检测肥大细胞增多症患者组织中HDC的表达，发现HDC水平升高与组胺过度释放相关，提示其在疾病诊断中的潜在生物标志物作用。
2. **《Development of a Monoclonal Antibody Against Human HDC for Immunohistochemical Analysis》**
- 作者：Yamamoto K. et al. (2018)
- 摘要：报道了一种高特异性小鼠抗人HDC单克隆抗体的开发，验证了其在结直肠癌组织中的免疫组化应用，证实HDC阳性细胞与肿瘤微环境炎症反应相关。
3. **《HDC Antibody-Based Detection of Neuronal Histamine Synthesis in Alzheimer's Disease Models》**
- 作者：Chen L. & Müller T. (2021)
- 摘要：通过HDC抗体标记阿尔茨海默病模型小鼠脑组织，发现神经元HDC表达异常与组胺能神经退行性病变存在关联，为病理机制研究提供新方向。
(注：以上文献为示例，实际引用需根据具体研究查询真实数据库如PubMed。)
Histidine decarboxylase (HDC) is an enzyme that catalyzes the conversion of histidine to histamine, a critical biogenic amine involved in immune responses, gastric acid secretion, and neurotransmission. Antibodies targeting HDC are essential tools for studying histamine biosynthesis and its role in physiological and pathological processes.
HDC antibodies are widely used in research to detect and quantify HDC expression in tissues or cells, particularly in neuroendocrine cells, mast cells, and certain tumors. For example, they help investigate conditions like mast cell disorders, neuroendocrine tumors (e.g., carcinoid tumors), and gastrointestinal diseases linked to dysregulated histamine production. In autoimmune contexts, anti-HDC autoantibodies have been identified in some autoimmune gastritis cases (e.g., type A gastritis), where they may contribute to parietal cell destruction, though their clinical significance remains under study.
These antibodies are also employed in diagnostic assays, including immunohistochemistry (IHC) and Western blotting, to differentiate histamine-dependent pathologies from other disorders. Monoclonal HDC antibodies offer high specificity, while polyclonal versions may detect diverse epitopes. Recent studies explore their potential in targeting histamine pathways for therapeutic modulation, such as in allergies or cancer immunotherapy. Overall, HDC antibodies bridge basic research and clinical applications, enhancing understanding of histamine-related mechanisms and diseases.
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