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Rabbit Polyclonal GNRH1 Antibody

  • 中文名： GNRH1抗体
  • 别    名： GRH; GNRH; HH12; LHRH; LNRH
货号: IPDX07420
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/300 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/2000-1/10000 Human,Mouse,Rat

产品详情

AliasesGRH; GNRH; HH12; LHRH; LNRH
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human GNRH1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于GNRH1抗体的3篇代表性文献示例(文献信息为模拟示例，仅供参考)：

1. **文献名称**：*Monoclonal Antibody Characterization of GNRH1 in Human Hypothalamic Neurons*

**作者**：Smith A, et al.

**摘要**：该研究通过开发特异性单克隆抗体，定位并验证了GNRH1在人类下丘脑神经元中的表达，揭示其与生殖激素调控的关联。

2. **文献名称**：*GNRH1 Antibody-Based Detection in Prostate Cancer Tissues*

**作者**：Lee C, et al.

**摘要**：利用GNRH1多克隆抗体分析前列腺癌组织中GNRH1的异常表达，提出其可能作为癌症诊断的生物标志物。

3. **文献名称**：*Structural Mapping of GNRH1 Epitopes Using Polyclonal Antibodies*

**作者**：Wang D, et al.

**摘要**：通过多克隆抗体对GNRH1蛋白的抗原表位进行系统性鉴定，为靶向治疗药物的开发提供结构基础。

注：以上文献为示例，实际研究中建议通过PubMed或Google Scholar检索最新文献，关键词如“GNRH1 antibody”、“GnRH1 immunohistochemistry”等。

背景信息

Gonadotropin-releasing hormone 1 (GNRH1), also known as luteinizing hormone-releasing hormone (LHRH), is a decapeptide produced in the hypothalamus. It plays a pivotal role in regulating reproductive physiology by stimulating the secretion of gonadotropins (LH and FSH) from the pituitary gland, which in turn control steroidogenesis and gametogenesis in the gonads. GNRH1 antibodies are immunodetection tools designed to target and bind specific epitopes of the GNRH1 peptide or its precursor proteins. These antibodies are widely used in research to study the expression, localization, and regulatory mechanisms of GNRH1 in hypothalamic neurons, as well as its involvement in reproductive disorders such as hypogonadism, infertility, and hormone-dependent cancers. In clinical diagnostics, they aid in assessing hypothalamic-pituitary-gonadal axis dysfunction. Additionally, GNRH1 antibodies have therapeutic potential, including the development of immunocontraceptives or treatments for conditions like prostate cancer, where GNRH1 signaling suppression is beneficial. Validation of these antibodies requires careful consideration of specificity due to structural similarities with related peptides across species. Their applications span immunohistochemistry, ELISA, and Western blot, contributing to both basic endocrine research and translational medicine.

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