关键信息
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基因名
SLC17A3
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简介
SLC17A3 is a voltage-driven organic anion transporter that plays a critical role in the renal proximal tubule. It actively promotes urate secretion and is essential for the elimination of the end products of purine metabolism. SLC17A3 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC17A3 protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.
- 应用
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别名
SLC17A3; Sodium-dependent phosphate transport protein 4; Na(+)/PI cotransporter 4; Sodium/phosphate cotransporter 4; Solute carrier family 17 member 3
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种属
Human
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表达系统
Baculovirus
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标签
N-MBP;C-Flag;N-8*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O00476
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表达区间
A2-L420
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蛋白长度
Full Length
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
SLC17A3, also known as the sodium-dependent inorganic phosphate transporter 3, is a member of the solute carrier family that plays a crucial role in phosphate homeostasis and cellular transport processes. Its primary function involves the uptake of inorganic phosphate from extracellular space, which is vital for various physiological processes, including bone mineralization, energy metabolism, and cellular signaling. Dysregulation of SLC17A3 has been associated with various pathological conditions, including chronic kidney disease and osteomalacia, highlighting its importance in both health and disease. Research into the recombinant protein of SLC17A3 aims to elucidate its structural and functional characteristics, facilitating better understanding of its transport mechanisms and potential regulatory pathways. By producing a recombinant version of this protein, scientists can conduct detailed functional assays, evaluate its interaction with other cellular components, and explore the impact of different substrates and inhibitors. Additionally, these studies can provide insights into therapeutic targets for managing disorders linked to phosphate imbalance. Consequently, SLC17A3 recombinant protein research holds significant promise in advancing our knowledge of phosphate transport processes and developing novel interventions for related diseases.
