| WB | 1/200-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | SGIII |
| WB Predicted band size | 53 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human SCG3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SCG3抗体的3篇示例参考文献及其摘要概括(注：以下内容为假设性示例，实际文献需通过学术数据库查询)：
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1. **文献名称**：SCG3 as a Novel Biomarker for Neuroendocrine Tumors: Diagnostic Implications
**作者**：Smith A, et al.
**摘要**：本研究探讨了SCG3抗体在神经内分泌肿瘤(NETs)诊断中的应用。通过免疫组化分析，发现SCG3在NETs组织中高表达，其抗体可有效区分NETs与其他上皮源性肿瘤，提示其作为特异性诊断标志物的潜力。
2. **文献名称**：Targeting SCG3 with Monoclonal Antibodies Inhibits Tumor Angiogenesis in Mouse Models
**作者**：Lee B, et al.
**摘要**：研究开发了靶向SCG3的单克隆抗体，并在小鼠模型中验证其抗血管生成作用。结果显示，SCG3抗体通过阻断SCG3与血管内皮生长因子(VEGF)的相互作用，显著抑制肿瘤血管形成和转移。
3. **文献名称**：SCG3 Expression in Pancreatic Cancer: Correlation with Prognosis and Therapeutic Targeting
**作者**：Wang X, et al.
**摘要**：分析了SCG3在胰腺癌中的表达及其临床意义。利用SCG3抗体检测发现，SCG3高表达与患者不良预后相关，体外实验证实抗体介导的SCG3抑制可增强化疗药物敏感性。
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如需获取真实文献，建议通过PubMed、Google Scholar等平台检索关键词“SCG3 antibody”、“Secretogranin III”或结合研究领域(如“cancer”、“neuroendocrine”)。
**Background of SCG3 Antibody**
Secretogranin III (SCG3), a member of the granin family of secretory proteins, is primarily involved in regulating secretory pathways within neuroendocrine and endocrine cells. It plays a role in hormone and neuropeptide storage, secretion, and granulogenesis, often acting as a chaperone for prohormones. SCG3 is highly expressed in neuroendocrine tissues and certain cancers, making it a potential biomarker or therapeutic target.
The SCG3 antibody is a tool designed to detect and quantify SCG3 protein levels in research applications. It is commonly used in techniques like immunohistochemistry (IHC), western blotting (WB), and immunofluorescence (IF) to study SCG3's expression, localization, and function in cellular or tissue samples. Polyclonal or monoclonal SCG3 antibodies are generated using specific antigenic epitopes of the protein, validated for specificity and sensitivity.
Research on SCG3 has gained attention in oncology, particularly in neuroendocrine tumors (NETs), pancreatic cancer, and diseases involving dysregulated secretion, such as diabetes or Alzheimer's. SCG3 antibodies help elucidate its role in tumor progression, hormone secretion, and cellular stress responses. Additionally, SCG3 is explored as a target for antibody-based therapies or imaging agents due to its restricted expression in pathological conditions. Overall, SCG3 antibodies are vital for advancing understanding of secretory mechanisms and disease-related pathways.
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