| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ABC; LAN; PRP; umat; MTABC3 |
| WB Predicted band size | 94 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human ABCB6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ABCB6抗体的3篇示例参考文献(内容为模拟概括，非真实文献)：
1. **文献名称**：*ABCB6 Antibody Characterization in Drug-Resistant Cancer Cell Lines*
**作者**：Smith J, et al.
**摘要**：通过特异性ABCB6抗体验证其在多种癌症细胞系中的表达，发现ABCB6过表达与化疗药物外排及耐药性相关，提示其作为耐药标志物的潜力。
2. **文献名称**：*Subcellular Localization of ABCB6 Using Immunofluorescence Staining*
**作者**：Zhang L, et al.
**摘要**：利用ABCB6抗体进行亚细胞定位研究，证实其在线粒体和溶酶体膜上的双重分布，为研究其铁卟啉转运功能提供实验依据。
3. **文献名称**：*ABCB6 Gene Regulation and Protein Expression in Liver Disease*
**作者**：Tanaka K, et al.
**摘要**：通过Western blot和免疫组化分析ABCB6抗体，发现肝脏疾病中ABCB6表达上调，可能与血红素代谢异常及氧化应激反应相关。
4. **文献名称**：*Evaluation of Commercial ABCB6 Antibodies for Specificity and Sensitivity*
**作者**：Müller R, et al.
**摘要**：系统评估市售ABCB6抗体的性能，发现部分抗体存在非特异性结合，推荐使用C末端特异性抗体以提高实验可靠性。
(注：以上文献信息为基于领域知识的模拟生成，实际引用请以真实论文为准。)
**Background of ABCB6 Antibody**
The ABCB6 antibody is a research tool targeting the ATP-binding cassette subfamily B member 6 (ABCB6) protein, a transporter within the ATP-binding cassette (ABC) superfamily. ABCB6 is implicated in multiple cellular processes, including porphyrin transport, heme biosynthesis, and mitochondrial function. It localizes to both the outer mitochondrial membrane and lysosomal membranes, suggesting roles in intracellular organelle communication and iron metabolism.
ABCB6 antibodies are widely used to study protein expression, localization, and function in various tissues and disease models. Dysregulation of ABCB6 has been linked to disorders such as iron-overload syndromes, chemotherapy resistance in cancers, and the rare genetic disorder dyschromatosis universalis hereditaria (DUH). Research utilizing these antibodies has revealed ABCB6's potential as a biomarker in cancer prognosis and its involvement in cellular detoxification pathways.
Antibody specificity is critical, as ABCB6 shares structural homology with other ABC transporters. Validation via knockout controls or siRNA-mediated silencing is often required. Commercial ABCB6 antibodies are typically developed in hosts like rabbits or mice, targeting specific epitopes (e.g., N-terminal or cytoplasmic domains). Applications include Western blotting, immunohistochemistry, and immunofluorescence, aiding in elucidating ABCB6's role in health and disease. Ongoing studies focus on its therapeutic potential in modulating drug resistance and metabolic disorders.
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