| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | DAC; CES5A1 |
| WB Predicted band size | 46 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human AADAC |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于AADAC抗体的3篇模拟参考文献示例(注：以下内容为示例，非真实文献)：
1. **标题**: "Development and Characterization of a Monoclonal Antibody Specific for Human AADAC"
**作者**: Tanaka K, et al.
**摘要**: 本研究开发了一种针对人源AADAC蛋白的单克隆抗体，验证了其在Western blot和免疫组化中的特异性，并用于分析AADAC在肝组织中的表达分布。
2. **标题**: "AADAC Enzyme Activity and Its Role in Drug Metabolism: Insights from Immunohistochemical Analysis"
**作者**: Smith J, et al.
**摘要**: 通过使用特异性AADAC抗体，该研究揭示了AADAC在肠道和肝脏中的细胞定位，并探讨了其与某些药物代谢个体差异的关联。
3. **标题**: "AADAC Expression in Hepatocellular Carcinoma: Correlation with Clinical Outcomes"
**作者**: Chen L, et al.
**摘要**: 利用AADAC抗体对肝癌组织进行检测，发现AADAC表达水平与患者预后显著相关，提示其作为潜在生物标志物的价值。
如需真实文献，建议在PubMed或Google Scholar中检索关键词“AADAC antibody”或“Arylacetamide deacetylase antibody”。
The arylacetamide deacetylase (AADAC) antibody is a research tool targeting the AADAC enzyme, a hydrolytic protein primarily expressed in the liver and gastrointestinal tract. AADAC plays a critical role in xenobiotic metabolism, catalyzing the deacetylation of arylacetamide substrates, including certain drugs (e.g., rifamycin) and environmental toxins. It also participates in lipid metabolism, influencing triglyceride hydrolysis and cholesterol homeostasis. Dysregulation of AADAC has been linked to metabolic disorders, drug toxicity, and cancers, particularly hepatocellular carcinoma and colorectal cancer.
AADAC antibodies, typically developed in hosts like rabbits or mice, enable the detection and quantification of AADAC protein levels in tissues or cell lysates via techniques like Western blotting, immunohistochemistry, and ELISA. These antibodies aid in studying AADAC's tissue distribution, regulatory mechanisms, and pathological roles. Recent research highlights AADAC's potential as a biomarker for metabolic syndrome or chemotherapeutic response. However, challenges remain in standardizing antibody specificity due to sequence homology with other esterases. Ongoing studies focus on clarifying AADAC's interactions with endogenous substrates and its impact on drug efficacy, underscoring its therapeutic and diagnostic relevance.
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