| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | RLI; OABP; ABC38; RNS4I; RNASEL1; RNASELI |
| WB Predicted band size | 67 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human ABCE1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于ABCE1抗体的相关文献概览：
1. **文献名称**: "ABCE1: A novel biomarker for hepatocellular carcinoma progression and prognosis"
**作者**: Li X, et al.
**摘要**: 研究利用ABCE1抗体通过免疫组化分析肝癌组织中ABCE1蛋白表达，发现其高表达与肿瘤转移和患者生存率下降显著相关，提示ABCE1可作为肝癌预后标志物。
2. **文献名称**: "ABCE1 regulates HIV-1 capsid assembly and viral infectivity via interaction with viral proteins"
**作者**: Zimmerman C, et al.
**摘要**: 通过Western blot和免疫共沉淀技术，研究发现ABCE1抗体可特异性识别病毒颗粒中的ABCE1蛋白，揭示其与HIV-1衣壳蛋白相互作用，影响病毒组装和感染能力。
3. **文献名称**: "ABCE1 is essential for ribosome recycling and translation termination in mammalian cells"
**作者**: Chen Y, et al.
**摘要**: 使用ABCE1抗体进行细胞免疫荧光定位，发现ABCE1定位于核周区域，并通过siRNA敲低实验验证其在核糖体循环和翻译终止中的关键作用，为真核细胞翻译机制提供新证据。
注：上述文献为示例性内容，实际文献需通过PubMed或Google Scholar检索确认。建议使用关键词"ABCE1 antibody"或"ABCE1 immunolocalization"查找具体研究。
ABCE1 (ATP-binding cassette sub-family E member 1), also known as RNase L inhibitor (RLI), is a conserved eukaryotic protein with dual roles in fundamental cellular processes. It belongs to the ATP-binding cassette (ABC) transporter superfamily but lacks transmembrane domains, distinguishing it from classical ABC transporters. Structurally, ABCE1 contains two nucleotide-binding domains and an iron-sulfur cluster, critical for its ATPase activity. Functionally, it is essential for ribosome biogenesis and translation termination, interacting with release factors to dissociate ribosomes after protein synthesis. Additionally, ABCE1 regulates innate immunity by inhibiting RNase L, an endoribonuclease activated during viral infections to degrade viral and host RNA. This dual role links ABCE1 to viral pathogenesis and interferon-mediated antiviral responses.
ABCE1 antibodies are vital tools for studying its expression, localization, and interactions. They enable detection via techniques like Western blot, immunofluorescence, and immunoprecipitation, aiding research on its roles in cell proliferation, viral defense, and cancer. Dysregulation of ABCE1 has been implicated in tumor progression, HIV replication, and neurodegenerative diseases, making it a potential therapeutic target. Antibodies targeting specific epitopes help dissect its molecular mechanisms and validate its involvement in disease pathways. As ABCE1 is ubiquitously expressed and evolutionarily conserved (from archaea to humans), these antibodies also facilitate cross-species comparative studies. Their applications span virology, oncology, and translational research, underscoring ABCE1's multifaceted biological significance.
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