关键信息
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基因名
APEG1
- 应用
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别名
Aortic preferentially expressed protein 1 ;APEG-1
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种属
Human
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表达系统
E. coli
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标签
N- GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q15772
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表达区间
1-113aa
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分子量
38.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
APEG1 (also known as APEH1 or AP-endonuclease 1) is a crucial enzyme involved in DNA repair mechanisms, particularly in the base excision repair (BER) pathway. This pathway is essential for maintaining genomic stability by correcting DNA damage caused by oxidative stress, environmental factors, and normal metabolic processes. Aberrant functioning or expression of APEG1 has been linked to various diseases, including cancer, neurodegenerative disorders, and other pathologies characterized by genomic instability. Recent studies have highlighted the importance of APEG1 in cellular responses to DNA damage and its potential as a therapeutic target. Researchers have been focusing on the structural and functional characterization of APEG1, aiming to elucidate its role in both healthy and diseased states. Recombining APEG1 in a laboratory setting allows scientists to investigate its enzymatic activity, substrate affinity, and interactions with other proteins involved in DNA repair. Such research holds promise for developing novel strategies for enhancing DNA repair mechanisms in clinical situations and offers insights into the enzyme's involvement in the cellular response to therapeutic interventions, thereby advancing our understanding of cancer biology and treatment approaches.
