| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/15-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | ARP11; ARP3BETA |
| WB Predicted band size | 48 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human ACTR3B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于ACTR3B抗体的3-4篇虚构参考文献示例(基于典型研究主题，非真实文献)：
---
1. **文献名称**: *"ACTR3B regulates actin polymerization dynamics in cancer cell motility"*
**作者**: Smith A, et al. (2015)
**摘要**: 本研究利用ACTR3B特异性抗体，通过免疫沉淀和免疫印迹技术，揭示了ACTR3B与ARP2/3复合体的相互作用机制，并证明其在乳腺癌细胞迁移中的关键调控作用。
2. **文献名称**: *"Prognostic value of ACTR3B overexpression in triple-negative breast cancer"*
**作者**: Jones R, et al. (2018)
**摘要**: 通过免疫组化(使用ACTR3B抗体)分析临床样本，发现ACTR3B在三阴性乳腺癌中高表达，且与患者总生存期缩短显著相关，提示其作为潜在预后标志物的价值。
3. **文献名称**: *"Validation of a novel monoclonal antibody for ACTR3B in human tissues"*
**作者**: Lee C, et al. (2020)
**摘要**: 报道了一种高特异性ACTR3B单克隆抗体的开发与验证，通过CRISPR敲除实验和质谱分析确认其特异性，并应用于亚细胞定位成像研究。
4. **文献名称**: *"ACTR3B-mediated actin remodeling in viral entry pathways"*
**作者**: Zhang Y, et al. (2022)
**摘要**: 使用ACTR3B抗体进行共聚焦显微镜分析，发现宿主细胞ACTR3B蛋白被某些包膜病毒劫持以促进膜融合和胞内运输，为抗病毒靶点研究提供新方向。
---
注：以上文献为模拟示例，实际引用时请核实真实出版物。如需真实文献，建议在PubMed或Google Scholar中检索关键词“ACTR3B antibody”。
ACTR3B (ARP3 Beta) is a subunit of the ARP2/3 (Actin-Related Protein 2/3) complex, a key regulator of actin cytoskeleton dynamics. This complex facilitates the nucleation of branched actin filaments, critical for cellular processes like migration, adhesion, and membrane remodeling. ACTR3B, a homolog of ACTR3 (ARP3), shares structural similarities but exhibits distinct tissue-specific expression patterns, with higher levels observed in hormone-responsive tissues such as the breast, ovary, and prostate. Its dysregulation has been implicated in cancer progression, particularly in breast cancer, where elevated ACTR3B expression correlates with metastatic potential and poor prognosis.
ACTR3B antibodies are essential tools for studying the protein's localization, expression, and function in both physiological and pathological contexts. They are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to assess ACTR3B levels in cell lines, tissues, or clinical samples. Research utilizing these antibodies has highlighted ACTR3B's role in regulating cell invasion by modulating actin polymerization and its interaction with signaling pathways involved in tumor metastasis. Additionally, ACTR3B antibodies aid in exploring its potential as a biomarker for cancer aggressiveness or as a therapeutic target. Commercial antibodies are typically developed against specific epitopes, often within conserved regions of the protein, and require validation for species cross-reactivity and application-specific performance.
×
