| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | AIP1; ARIP1; ARPT1; HSD27 |
| WB Predicted band size | 42 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human ACTRT1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇涉及ACTRT1抗体的参考文献(部分信息为模拟示例，实际文献可能需要通过学术数据库检索确认)：
1. **标题**: "ACTRT1 regulates cytoskeletal dynamics in cancer cell migration"
**作者**: Li X, et al.
**摘要**: 本研究利用ACTRT1特异性抗体，发现ACTRT1通过与Arp2/3复合物互作调控乳腺癌细胞伪足形成，抑制其表达可显著降低细胞侵袭能力。
2. **标题**: "Characterization of ACTRT1 antibody for immunofluorescence applications"
**作者**: Wang Y, et al.
**摘要**: 文章验证了ACTRT1多克隆抗体在HeLa细胞中的特异性，证实其在免疫荧光和Western blot中的有效性，为细胞骨架研究提供工具支持。
3. **标题**: "ACTRT1 interacts with SMAD4 to modulate TGF-β signaling in fibrosis"
**作者**: Chen J, et al.
**摘要**: 通过ACTRT1抗体共免疫沉淀实验，揭示了ACTRT1与SMAD4的相互作用，表明其在TGF-β通路和肺纤维化病理过程中的调控作用。
注：以上文献为示例性内容，实际研究中建议通过PubMed、Google Scholar等平台以关键词“ACTRT1 antibody”或“ACTRT1 immunological tool”检索最新文献。部分研究可能以ACTRT1的别名(如ARP-T1)出现。
ACTRT1 (actin-related protein T1) is a less-characterized member of the actin-related protein (Arp) family, which shares structural similarities with conventional actin but performs specialized cellular functions. It is implicated in regulating cytoskeletal dynamics, intracellular trafficking, and chromatin remodeling. ACTRT1 is thought to interact with other Arp complex components to modulate actin filament organization, influencing cell motility, division, and signaling pathways. Its expression has been detected in various tissues, with emerging research suggesting potential roles in cancer progression, neuronal development, and reproductive biology.
ACTRT1 antibodies are immunodetection tools developed to study the protein’s expression, localization, and interactions. These antibodies are commonly used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to map ACTRT1 distribution in cellular compartments or tissue samples. Recent studies have explored ACTRT1’s overexpression in certain cancers, linking it to tumor invasiveness and metastasis, which positions ACTRT1 antibodies as potential diagnostic or prognostic biomarkers. However, the protein’s functional mechanisms remain under investigation, partly due to its low abundance and overlapping roles with other Arps. Researchers emphasize antibody validation using knockout controls to ensure specificity, as cross-reactivity with homologous proteins is a common challenge. Ongoing work aims to elucidate ACTRT1’s precise contributions to cellular processes and disease contexts, leveraging these antibodies for mechanistic and translational studies.
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