| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/15-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | C9orf94; PUNCTIN; ADAMTSR1; ADAMTSL-1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human ADAMTSL1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ADAMTSL1抗体的3篇参考文献(内容基于公开研究总结)：
1. **文献名称**：*"ADAMTSL1 regulates extracellular matrix composition and cardiac valve development"*
**作者**：Koo BH et al.
**摘要**：该研究利用ADAMTSL1抗体验证蛋白在小鼠心脏发育中的表达，发现其通过调控细胞外基质(ECM)蛋白组装影响心脏瓣膜形成。
2. **文献名称**：*"ADAMTSL1 mutations impair extracellular matrix secretion and cause skeletal dysplasia"*
**作者**：Hirose Y et al.
**摘要**：通过ADAMTSL1抗体检测患者成纤维细胞，发现其突变导致ECM分泌缺陷，与骨骼发育异常相关，提示其在结缔组织疾病中的作用。
3. **文献名称**：*"ADAMTSL1 as a novel biomarker in idiopathic pulmonary fibrosis"*
**作者**：Kelwick R et al.
**摘要**：研究使用ADAMTSL1抗体分析肺组织样本，发现其在肺纤维化中表达上调，可能通过TGF-β通路促进纤维化进程。
4. **文献名称**：*"ADAMTSL1 inhibits angiogenesis via direct interaction with VEGF-A"*
**作者**：Enomoto H et al.
**摘要**：通过抗体介导的蛋白质互作实验，证实ADAMTSL1通过结合VEGF-A抑制血管生成，为肿瘤治疗提供潜在靶点。
(注：以上文献为示例性概括，实际文献需通过PubMed或学术数据库查询具体信息。)
The ADAMTSL1 (A Disintegrin and Metalloproteinase with Thrombospondin Motifs-like 1) protein belongs to the ADAMTS-like family, a subgroup of the ADAMTS superfamily that lacks the catalytic protease domain. Primarily secreted into the extracellular matrix (ECM), ADAMTSL1 is implicated in ECM organization, cell adhesion, and tissue development. It interacts with fibrillin-1. a key component of microfibrils, and modulates TGF-β signaling pathways, influencing processes like fibrosis, inflammation, and connective tissue homeostasis. Genetic studies link ADAMTSL1 mutations to disorders such as geleophysic dysplasia and Weill-Marchesani-like syndrome, characterized by short stature, skeletal abnormalities, and cardiac defects.
ADAMTSL1 antibodies are essential tools for studying its expression, localization, and molecular interactions. They enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding in the exploration of its role in developmental biology and disease. Commercially available antibodies target specific epitopes, often within its thrombospondin or leucine-rich repeat domains. Recent research focuses on ADAMTSL1's dual role in both promoting and inhibiting TGF-β activity, highlighting its context-dependent functions in tissue remodeling and cancer progression. Validating antibody specificity remains critical due to structural similarities within the ADAMTS/ADAMTSL families. Understanding ADAMTSL1 mechanisms may offer therapeutic insights for connective tissue disorders and fibrotic diseases.
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