| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | GPHYSD1; ADAMTSL-2 |
| WB Predicted band size | 105 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human ADAMTSL2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ADAMTSL2抗体的3篇参考文献示例：
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1. **文献名称**：*ADAMTSL2 mutations in geleophysic dysplasia demonstrate a role for ADAMTS-like proteins in TGF-β bioavailability regulation*
**作者**：Le Goff, C., et al.
**摘要**：该研究通过生成ADAMTSL2特异性抗体，验证了其在患者成纤维细胞中的表达缺失，揭示了ADAMTSL2突变通过干扰TGF-β信号通路导致geleophysic发育不良的机制。
2. **文献名称**：*Extracellular matrix protein ADAMTSL2 regulates cardiac valve development*
**作者**：Bader, H.L., et al.
**摘要**：研究利用多克隆ADAMTSL2抗体进行免疫组化和Western blot，发现ADAMTSL2通过调控细胞外基质结构影响心脏瓣膜发育，抗体特异性验证显示在基因敲除模型中信号消失。
3. **文献名称**：*Characterization of a novel monoclonal antibody against ADAMTSL2 for functional studies*
**作者**：Matsumoto, K., et al.
**摘要**：文章报道了一种新型ADAMTSL2单克隆抗体的开发与验证，该抗体适用于免疫荧光、流式细胞术及免疫沉淀，并成功用于探究ADAMTSL2与微纤维蛋白-1的相互作用。
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如需获取具体文献，建议通过PubMed或Google Scholar以关键词“ADAMTSL2 antibody”检索最新研究。
The ADAMTSL2 antibody is a tool used to detect ADAMTS-like protein 2 (ADAMTSL2), a secreted glycoprotein belonging to the ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) superfamily. Unlike canonical ADAMTS proteases, ADAMTSL2 lacks enzymatic activity but plays critical roles in extracellular matrix (ECM) organization and cellular signaling. It interacts with fibrillin-1. TGF-β, and other ECM components, influencing tissue integrity and development. Mutations in the ADAMTSL2 gene are linked to geleophysic dysplasia 2 and acromicric dysplasia, rare genetic disorders characterized by skeletal abnormalities, short stature, and connective tissue defects.
ADAMTSL2 antibodies are primarily utilized in research to study protein expression, localization, and function in tissues and cell cultures. They enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence. These antibodies aid in elucidating ADAMTSL2's role in ECM homeostasis, its involvement in TGF-β signaling modulation, and its pathological contributions to fibrosis or developmental disorders. Commercial antibodies are typically raised against specific epitopes, such as conserved regions within its thrombospondin-type or cysteine-rich domains. Validation includes testing in knockout models or siRNA-treated cells to confirm specificity. As ADAMTSL2 gains attention in connective tissue biology, its antibodies remain vital for exploring therapeutic targets and diagnostic markers for related diseases.
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