| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | KNO2; ADAMTS21 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human ADAMTS18 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ADAMTS18抗体的3篇虚构参考文献(基于研究领域常见主题模拟，非真实文献)：
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1. **文献名称**: "ADAMTS18 Antibody Characterization and Its Role in Tumor Angiogenesis"
**作者**: Zhang L, et al.
**摘要**: 本研究通过制备高特异性ADAMTS18多克隆抗体，验证其在多种癌细胞系中的表达下调，并发现ADAMTS18通过调控VEGF信号通路抑制肿瘤血管生成，提示其作为潜在肿瘤标志物的价值。
2. **文献名称**: "ADAMTS18 Deficiency and Cerebral Aneurysm Formation: Insights from Antibody-Based Immunohistochemistry"
**作者**: Tanaka K, et al.
**摘要**: 利用ADAMTS18抗体进行组织染色分析，发现ADAMTS18在脑血管壁中高表达，其缺失会导致细胞外基质(ECM)结构异常，增加颅内动脉瘤风险，为脑血管疾病机制提供新证据。
3. **文献名称**: "Development of a Monoclonal Antibody Targeting ADAMTS18 for Early-Stage Colorectal Cancer Detection"
**作者**: Wang Y, et al.
**摘要**: 报道一种新型ADAMTS18单克隆抗体的开发，通过ELISA和免疫组化验证其在结直肠癌患者血清及组织样本中的高灵敏度检测能力，表明ADAMTS18可能成为早期诊断的生物标志物。
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注：以上文献为模拟内容，实际研究中请通过PubMed或Web of Science等数据库查询真实文献。
The ADAMTS18 antibody is designed to target the ADAMTS18 (A Disintegrin and Metalloproteinase with Thrombospondin Motifs 18) protein, a member of the ADAMTS family of secreted zinc-dependent proteases. These enzymes play critical roles in extracellular matrix (ECM) remodeling, cell adhesion, and proteolytic processing of bioactive molecules. ADAMTS18 is implicated in various physiological and pathological processes, including tissue development, angiogenesis, and hemostasis. Research links it to cancer progression, where it may act as a tumor suppressor by modulating cell proliferation and metastasis, and to ocular disorders like familial keratoconus and retinal degeneration. Mutations in ADAMTS18 are associated with genetic diseases affecting connective tissues and vascular integrity.
ADAMTS18 antibodies are essential tools for studying the protein's expression, localization, and function in disease models. They enable detection via techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Recent studies explore its potential as a biomarker for early cancer diagnosis or prognosis. However, the precise mechanisms of ADAMTS18 in ECM dynamics and signaling pathways remain incompletely understood, necessitating further research. The development of specific and validated ADAMTS18 antibodies is crucial for advancing therapeutic strategies, including targeting its enzymatic activity or ECM interactions in diseases like fibrosis, cancer, and inherited connective tissue disorders.
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