| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | AK |
| WB Predicted band size | 41 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human ADK |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ADK(腺苷激酶)抗体的3篇文献示例及其摘要概括：
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1. **文献名称**：*Selective Antibodies for the Immunodetection of Adenosine Kinase Isoforms in Brain Tissue*
**作者**：Bojinov et al. (2015)
**摘要**：该研究开发了针对ADK长亚型(ADK-L)和短亚型(ADK-S)的特异性抗体，用于区分两者在脑组织中的分布。实验表明ADK-L在星形胶质细胞中高表达，而ADK-S在神经元中富集，为研究腺苷代谢与癫痫的关系提供了工具。
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2. **文献名称**：*Adenosine Kinase Expression in Glioblastoma: A Therapeutic Target via Modulation of Tumor Microenvironment*
**作者**：Park et al. (2018)
**摘要**：通过ADK抗体的免疫组化分析，发现胶质母细胞瘤中ADK表达显著上调，并与肿瘤微环境中的腺苷水平相关。抑制ADK可减少肿瘤增殖，提示其作为潜在治疗靶点。
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3. **文献名称**：*Role of Adenosine Kinase in Hepatic Ischemia-Reperfusion Injury*
**作者**：Zhang et al. (2020)
**摘要**：利用ADK抗体检测小鼠肝脏缺血再灌注模型中ADK的动态变化，发现ADK活性升高导致局部腺苷耗竭，加剧炎症反应。该研究支持ADK抑制剂在减轻器官损伤中的应用。
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**注**：以上文献信息为示例性内容，实际引用需以真实发表的论文为准。建议通过PubMed、Google Scholar等平台检索关键词“Adenosine Kinase antibody”获取最新文献。
Adenosine kinase (ADK) antibodies are tools used to detect and study adenosine kinase, an enzyme critical in purine metabolism. ADK catalyzes the phosphorylation of adenosine into adenosine monophosphate (AMP), regulating intracellular adenosine levels. This enzyme plays a dual role: sustaining nucleotide homeostasis and modulating adenosine-mediated signaling pathways, which influence processes like inflammation, neurotransmission, and cell survival. Dysregulation of ADK is linked to neurological disorders (e.g., epilepsy), cancer, and metabolic conditions, making it a research focus for therapeutic targeting.
ADK antibodies are essential in biomedical research to investigate ADK expression, localization, and function in tissues or cell lines. They enable techniques such as Western blotting, immunohistochemistry, and immunofluorescence, helping to map ADK distribution in the brain, liver, and proliferating cells. Species-specific ADK antibodies (e.g., human, mouse, rat) facilitate cross-species studies, while phosphorylation-specific variants aid in analyzing post-translational modifications. Validation of these antibodies ensures specificity, minimizing cross-reactivity with related kinases. Recent studies also explore ADK's role in epigenetic regulation via its interaction with methylation pathways, expanding its relevance in disease mechanisms. Researchers rely on ADK antibodies to uncover its therapeutic potential in disorders involving adenosine imbalance.
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