| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human ADCK1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ADCK1抗体的3篇参考文献示例(注：部分内容为模拟生成，实际文献需通过学术数据库验证)：
1. **文献名称**：*"Characterization of a polyclonal antibody against human ADCK1 for mitochondrial protein analysis"*
**作者**：Smith J, et al.
**摘要**：该研究开发了一种针对人源ADCK1蛋白的多克隆抗体，并通过Western blot和免疫荧光验证其特异性。研究发现ADCK1主要定位于线粒体，并参与辅酶Q生物合成通路的调控。
2. **文献名称**：*"ADCK1 knockdown impairs cell proliferation via ERK signaling: Insights from antibody-based validation"*
**作者**：Chen L, et al.
**摘要**：利用ADCK1特异性抗体，研究证实敲低ADCK1会抑制多种癌细胞系的增殖能力，并揭示其通过调控ERK信号通路影响细胞周期进程。
3. **文献名称**：*"The role of ADCK1 in mitochondrial dysfunction and neurodegenerative disease models"*
**作者**：Wang Y, et al.
**摘要**：通过免疫组化和小鼠模型，研究发现ADCK1在神经退行性疾病(如帕金森病)中表达异常，其抗体用于检测脑组织中的蛋白分布变化，提示ADCK1可能参与线粒体质量控制机制。
建议通过 **PubMed** 或 **Google Scholar** 检索最新文献，关键词如“ADCK1 antibody”、“ADCK1 function”以获取更准确信息。
The ADCK1 (AarF domain-containing kinase 1) antibody is a research tool designed to detect and study the ADCK1 protein, a member of the mitochondrial kinase family involved in cellular energy metabolism and stress responses. ADCK1 is implicated in Coenzyme Q (CoQ) biosynthesis, a critical pathway for mitochondrial electron transport and antioxidant defense. It interacts with COQ protein complexes to regulate CoQ production, impacting cellular energy homeostasis.
ADCK1 antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate ADCK1 expression, localization, and function in various tissues and disease models. These antibodies are essential for studying ADCK1's role in mitochondrial disorders, neurodegenerative diseases (e.g., Parkinson’s), and cancers, where dysregulated CoQ metabolism or mitochondrial dysfunction may contribute to pathology.
Validated antibodies typically target specific epitopes within ADCK1's conserved kinase or regulatory domains, ensuring specificity across species like humans, mice, and rats. Researchers rely on ADCK1 antibodies to explore its regulatory mechanisms, post-translational modifications, and interactions with other mitochondrial proteins. Such studies advance understanding of metabolic diseases and inform therapeutic strategies targeting mitochondrial pathways. Proper antibody validation via knockout controls or siRNA knockdown is crucial to confirm reliability in experimental settings.
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