| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | M12.219 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human ADAMDEC1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3-4条关于 **ADAMDEC1抗体** 的虚构参考文献示例(供参考，实际文献需查阅数据库)：
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1. **文献名称**：*"Development of a Monoclonal Antibody Targeting ADAMDEC1 and Its Application in Colorectal Cancer Detection"*
**作者**：Smith A, et al. (2020)
**摘要**：本研究开发了一种针对ADAMDEC1胞外域的高特异性单克隆抗体，验证了其在结直肠癌组织中的表达上调，并证明其可用于免疫组化检测，提示ADAMDEC1可能作为肿瘤进展的潜在标志物。
2. **文献名称**：*"ADAMDEC1 Expression in Immune Cells: Role in Inflammation and Antibody-Based Functional Analysis"*
**作者**：Johnson R, et al. (2018)
**摘要**：通过抗ADAMDEC1多克隆抗体，作者发现该蛋白在巨噬细胞和树突状细胞中特异性表达，并参与调控炎症反应中的基质降解，为自身免疫疾病治疗提供新靶点。
3. **文献名称**：*"Proteolytic Activity of ADAMDEC1 in Rheumatoid Arthritis: Inhibition by Neutralizing Antibodies"*
**作者**：Lee H, et al. (2019)
**摘要**：利用ADAMDEC1中和抗体阻断其蛋白水解活性，发现可显著减少类风湿关节炎模型中的关节破坏，表明其作为治疗性抗体的潜在价值。
4. **文献名称**：*"ADAMDEC1 as a Biomarker in Pancreatic Cancer: Validation via Immunohistochemistry and ELISA"*
**作者**：Brown K, et al. (2021)
**摘要**：通过商业化ADAMDEC1抗体进行组织微阵列分析，证实其在胰腺癌基质中高表达，且血清ADAMDEC1水平与患者生存率负相关。
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**注**：以上内容为模拟生成，实际文献请通过PubMed、Web of Science等平台检索关键词“ADAMDEC1 antibody”。
The ADAMDEC1 (A Disintegrin and Metalloproteinase Domain-Like Decysin 1) antibody targets a unique member of the ADAM family of proteases, which are involved in extracellular matrix remodeling, cell adhesion, and signaling. ADAMDEC1. also known as decysin-1. is distinct from other ADAM proteins due to its truncated structure, lacking a transmembrane domain and conserved cysteine-rich region, suggesting a specialized regulatory role. It is primarily expressed in immune cells, such as dendritic cells and macrophages, and is implicated in inflammatory processes, immune regulation, and cancer progression. Studies highlight its context-dependent functions: it may promote tumor growth in certain cancers (e.g., colorectal carcinoma) while acting as a tumor suppressor in others.
The ADAMDEC1 antibody is a critical tool for detecting and quantifying this protein in research. It enables the study of ADAMDEC1's expression patterns, localization, and interactions via techniques like Western blotting, immunohistochemistry, and flow cytometry. Its applications extend to exploring ADAMDEC1's role in diseases, including autoimmune disorders (e.g., rheumatoid arthritis) and infectious diseases. However, due to structural similarities within the ADAM family, antibody specificity must be rigorously validated using knockout controls or recombinant proteins. Commercial ADAMDEC1 antibodies are typically raised in rabbits or mice, with monoclonal and polyclonal variants available, tailored for different experimental needs.
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