| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | AC4 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human ADCY4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ADCY4抗体的模拟参考文献示例(仅供参考，非真实文献)：
1. **标题**："Characterization of ADCY4 Expression in Cardiomyopathy Using Specific Polyclonal Antibodies"
**作者**：Smith A, et al.
**摘要**：研究通过构建ADCY4特异性多克隆抗体，分析其在心肌病模型中的表达变化，发现ADCY4下调与cAMP信号通路异常相关。
2. **标题**："ADCY4 Antibody Validation for Immunohistochemistry in Colorectal Cancer Tissues"
**作者**：Li J, et al.
**摘要**：验证了ADCY4抗体在结直肠癌组织中的特异性，发现高表达ADCY4与肿瘤侵袭性相关，提示其作为潜在生物标志物的价值。
3. **标题**："Role of ADCY4 in Neuronal cAMP Signaling: Insights from Knockout Mice and Antibody-Based Localization"
**作者**：Garcia R, et al.
**摘要**：利用ADCY4抗体进行脑组织免疫荧光定位，揭示其在神经元突触中的分布，并通过基因敲除实验证明其对突触可塑性的调控作用。
**注意**：以上为模拟示例，建议通过PubMed、Google Scholar等平台检索真实文献(关键词：ADCY4 antibody, adenylyl cyclase 4. immunohistochemistry)。
The ADCY4 antibody is a research tool designed to detect adenylate cyclase 4 (ADCY4), a membrane-bound enzyme belonging to the adenylate cyclase family. ADCY4 catalyzes the conversion of ATP to cyclic AMP (cAMP), a critical secondary messenger regulating diverse cellular processes, including metabolism, gene expression, and cell signaling. Primarily expressed in the brain, heart, and lung tissues, ADCY4 is uniquely regulated by calcium/calmodulin signaling, distinguishing it from other isoforms. Its activity is linked to G protein-coupled receptor (GPCR) pathways, particularly those involving Gαs and Gαi subunits, which modulate cAMP levels in response to extracellular stimuli.
Research on ADCY4 has focused on its role in physiological and pathological conditions. Studies suggest its involvement in neurological disorders, cardiovascular diseases, and cancer, where dysregulated cAMP signaling contributes to disease progression. For example, ADCY4 mutations or altered expression have been implicated in bipolar disorder and heart failure. The ADCY4 antibody enables the detection and localization of ADCY4 in tissues or cultured cells, aiding investigations into its expression patterns, post-translational modifications, and interactions with regulatory proteins. It is commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Commercial ADCY4 antibodies are typically validated for specificity and sensitivity, though performance may vary between clones or hosts (e.g., rabbit, mouse). Ongoing research aims to clarify ADCY4's tissue-specific functions and therapeutic potential as a target for modulating cAMP-dependent pathways.
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