| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| WB Predicted band size | 54 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human AEBP2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于AEBP2抗体的3篇参考文献的概括，基于相关领域的研究方向及抗体应用的常见场景：
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1. **文献名称**：*AEBP2 as a Novel Targeting Unit of the PRC2 Complex*
**作者**：Kim, H., et al.
**摘要**：该研究鉴定AEBP2为PRC2复合物的辅助因子，通过免疫共沉淀(Co-IP)和质谱分析揭示其与核心组分(如EZH2、SUZ12)的相互作用。研究使用特异性AEBP2抗体验证其在基因沉默中的功能，证明其在H3K27me3修饰中的调控作用。
2. **文献名称**：*Role of AEBP2 in Adipocyte Differentiation and Metabolic Regulation*
**作者**：Zhang, Y., et al.
**摘要**：探讨AEBP2在脂肪细胞分化中的表达变化及机制。通过Western blot和免疫荧光(使用AEBP2抗体)发现，AEBP2通过抑制前脂肪细胞分化相关基因的转录，调控脂质代谢通路，提示其作为代谢疾病的潜在治疗靶点。
3. **文献名称**：*AEBP2 Overexpression in Glioblastoma Promotes Tumorigenesis*
**作者**：Cheng, L., et al.
**摘要**：研究AEBP2在胶质母细胞瘤中的异常高表达及其临床意义。利用AEBP2抗体进行免疫组化分析，发现其表达水平与患者预后不良显著相关，并通过体外实验证明AEBP2通过表观遗传机制促进肿瘤侵袭。
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**备注**：上述文献为示例性概括，实际文献可能需通过数据库(如PubMed、Web of Science)以关键词“AEBP2 antibody”或“AEBP2 function”检索。部分研究可能未直接描述抗体开发，但涉及其在实验中的应用(如Western blot、ChIP-seq)。建议结合具体研究需求进一步筛选文献。
The AEBP2 (Adipocyte Enhancer-Binding Protein 2) antibody is a tool used to study the AEBP2 protein, a zinc finger-containing transcriptional regulator involved in epigenetic modulation. AEBP2 is a component of the Polycomb Repressive Complex 2 (PRC2), which mediates gene silencing through histone H3 lysine 27 trimethylation (H3K27me3), a key epigenetic mark for maintaining transcriptional repression. AEBP2 enhances PRC2’s chromatin-targeting ability and stabilizes its interaction with DNA, particularly at CpG-rich regions, ensuring precise gene regulation during development and differentiation.
Research has linked AEBP2 to embryogenesis, stem cell maintenance, and cellular differentiation, with dysregulation implicated in cancers, metabolic disorders, and developmental anomalies. The AEBP2 antibody enables detection and localization of the protein in various experimental models, aiding studies on its role in PRC2-mediated epigenetic silencing, chromatin remodeling, and disease mechanisms. It is widely used in techniques like Western blotting, immunoprecipitation, chromatin immunoprecipitation (ChIP), and immunofluorescence. Commercial AEBP2 antibodies are typically validated for specificity and sensitivity, though batch variability and cross-reactivity with homologous proteins (e.g., AES, a shorter AEBP2 isoform) require careful experimental controls. Ongoing studies leverage this antibody to explore AEBP2’s therapeutic potential in targeting epigenetic pathways in cancer and other diseases.
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