Rabbit Polyclonal AGBL5 Antibody

The AGBL5 (ATP/GTP Binding Protein Like 5) antibody is a research tool designed to detect and study the AGBL5 protein, a member of the cytosolic carboxypeptidase (CCP) family. AGBL5. also known as CCP5. functions as a metalloenzyme that catalyzes the post-translational removal of glutamic acid residues (polyglutamylation) or aspartic acid residues from proteins, particularly targeting the C-terminal tails of α-tubulin. This enzymatic activity plays a critical role in regulating microtubule dynamics, which influences cellular processes such as mitosis, cilia formation, and neuronal development. AGBL5 is structurally characterized by a conserved N-terminal catalytic domain and a C-terminal domain involved in substrate recognition. Dysregulation of AGBL5 has been implicated in neurodegenerative disorders, cancer progression, and ciliopathies, making it a subject of interest in both basic and translational research. The AGBL5 antibody is widely utilized in techniques like Western blotting, immunofluorescence, and immunohistochemistry to assess protein expression, localization, and function in various biological models. Recent studies have highlighted its potential as a biomarker or therapeutic target, particularly in contexts like glioblastoma and Alzheimer’s disease, where altered microtubule stability is observed. Commercial AGBL5 antibodies are typically validated for specificity and sensitivity across human, mouse, and rat samples.