| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CCP3 |
| WB Predicted band size | 116 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human AGBL3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于AGBL3抗体的3篇示例参考文献(注：内容为虚构示例，实际文献需通过学术数据库检索确认)：
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1. **文献名称**：*"AGBL3 Antibody-Based Detection of Cytosolic Deteryrosination in Neuronal Cells"*
**作者**：Miller A, et al.
**摘要**：通过AGBL3特异性抗体进行免疫印迹和免疫荧光分析，揭示AGBL3在神经元细胞中调控α-微管蛋白去酪氨酸化的作用，影响轴突运输和神经退行性病变模型中的病理进展。
2. **文献名称**：*"Development of a Monoclonal Antibody Against AGBL3 for Cancer Biomarker Studies"*
**作者**：Wang X, et al.
**摘要**：报道一种高特异性抗AGBL3单克隆抗体的开发，并用于结直肠癌组织芯片的免疫组化分析，结果显示AGBL3低表达与肿瘤转移和患者生存率下降显著相关。
3. **文献名称**：*"AGBL3 Modulates Cellular Metabolism via Tubulin Modification: Insights from Knockout Mouse Models"*
**作者**：Garcia S, et al.
**摘要**：利用AGBL3抗体在基因敲除小鼠模型中验证蛋白表达缺失，结合代谢组学分析，提出AGBL3通过微管去酪氨酸化影响线粒体功能及能量代谢通路。
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**提示**：实际研究中，建议通过PubMed或Google Scholar以“AGBL3 antibody”或“AGBL3 + [研究领域]”为关键词检索最新文献，并关注抗体应用场景(如WB、IHC、功能研究)及疾病关联。
The AGBL3 (ATP/GTP Binding Protein-Like 3) antibody is a tool used to detect the AGBL3 protein, a member of the cytosolic carboxypeptidase (CCP) family. AGBL3. also known as CCP3. is a metalloprotease implicated in post-translational protein modification, particularly in the removal of C-terminal amino acids like glutamates or aspartates. This enzymatic activity is critical for regulating protein function, stability, and interactions. AGBL3 is closely related to other CCP family members, such as AGBL1 and AGBL2. which are involved in neuronal tubulin detyrosination—a process essential for microtubule dynamics and cellular processes like division and trafficking.
Research on AGBL3 is less extensive compared to its homologs, but studies suggest its potential role in cytoskeletal regulation and neurological functions. It is expressed in various tissues, including the brain, testis, and liver. Dysregulation of CCP family enzymes has been linked to neurodegenerative diseases and cancer, though AGBL3-specific mechanisms remain under investigation. The AGBL3 antibody is utilized in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study its expression, localization, and biological significance. Commercial antibodies are typically validated for specificity using knockout controls or siRNA-mediated silencing. Researchers employ this tool to explore AGBL3's involvement in cellular pathways, disease models, or as a biomarker, emphasizing the need for rigorous validation to ensure target specificity in experimental settings.
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