| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | ATRAP |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human AGTRAP |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于AGTRAP抗体的3篇参考文献示例(文献信息及内容为模拟虚构，仅供示例参考)：
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1. **文献名称**：*AGTRAP modulates angiotensin II receptor signaling in vascular smooth muscle cells*
**作者**：Li X, Zhang Y, et al.
**摘要**：本研究利用AGTRAP特异性抗体，通过免疫共沉淀和Western blot技术，揭示了AGTRAP蛋白与血管紧张素II 1型受体(AT1R)的相互作用，证实其通过抑制ERK1/2磷酸化调节血管收缩功能。
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2. **文献名称**：*AGTRAP as a potential biomarker in hypertensive patients: an immunohistochemical study*
**作者**：Wang H, Chen J, et al.
**摘要**：通过免疫组化分析人类肾脏组织样本，使用AGTRAP抗体发现高血压患者肾小管中AGTRAP表达显著上调，提示其可能参与血压调节及肾脏损伤的病理过程。
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3. **文献名称**：*Development and validation of a novel ELISA assay for AGTRAP detection using monoclonal antibodies*
**作者**：Sato K, Tanaka M, et al.
**摘要**：本研究开发了一种基于AGTRAP单克隆抗体的高灵敏度ELISA检测方法，验证了其在血浆样本中的稳定性和特异性，为心血管疾病的临床诊断提供了新工具。
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如需真实文献，建议通过PubMed或Google Scholar搜索关键词“AGTRAP antibody”或“AGTRAP + [疾病/功能]”获取最新研究。
The AGTRAP (Angiotensin II Receptor Associated Protein) antibody is a research tool designed to detect and study the AGTRAP protein, a component of the renin-angiotensin system (RAS) involved in blood pressure regulation and cardiovascular homeostasis. AGTRAP interacts with the angiotensin II type 1 receptor (AT1R), modulating its signaling and internalization. This protein is thought to act as a negative regulator of AT1R-mediated pathways, which influence vasoconstriction, aldosterone secretion, and vascular remodeling. Dysregulation of AGTRAP expression has been implicated in hypertension, heart failure, and other cardiovascular disorders.
Antibodies targeting AGTRAP are typically developed using immunogens derived from specific epitopes of the human or murine AGTRAP sequence. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein expression, localization, and interaction partners in tissues or cultured cells. Validation often includes knockout controls to confirm specificity.
Research utilizing AGTRAP antibodies aims to elucidate its role in AT1R trafficking, signal transduction, and pathological mechanisms underlying cardiovascular diseases. Additionally, these antibodies support drug discovery efforts targeting RAS-related pathways. Commercial AGTRAP antibodies vary in host species, clonality, and conjugation, with applications spanning basic research and preclinical studies. Proper validation remains critical due to potential cross-reactivity with homologous proteins in certain experimental models.
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