| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | CALS-7; MDS015; ALS2CR1 |
| WB Predicted band size | 42 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human NIF3L1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于NIF3L1抗体的3篇参考文献及其摘要概括：
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1. **文献名称**: **"NIF3L1 interacts with BRCA1 and regulates its DNA damage response function"**
**作者**: Smith A, et al.
**摘要**: 本研究揭示NIF3L1蛋白通过与BRCA1相互作用，参与DNA损伤修复调控。作者利用NIF3L1特异性抗体进行免疫共沉淀(Co-IP)和免疫荧光实验，发现NIF3L1缺失会导致BRCA1在DNA损伤位点的募集受阻，提示其在基因组稳定性中的关键作用。
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2. **文献名称**: **"Expression and functional analysis of NIF3L1 in hepatocellular carcinoma"**
**作者**: Zhang Y, et al.
**摘要**: 该研究通过Western blot和免疫组化(IHC)分析NIF3L1在肝癌组织中的表达水平，发现其表达与患者预后显著相关。使用NIF3L1抗体进一步验证其在肝癌细胞增殖和迁移中的抑制作用，表明其可能作为潜在治疗靶点。
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3. **文献名称**: **"NIF3L1 modulates cell cycle progression by interacting with CDK2"**
**作者**: Lee J, et al.
**摘要**: 本文发现NIF3L1通过与CDK2结合调控G1/S期转换。利用NIF3L1抗体进行免疫沉淀和蛋白质组学分析，证实其与CDK2复合物的相互作用，并揭示其在细胞周期检查点中的功能，为癌症治疗提供新视角。
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注：以上文献为示例，实际文献需通过数据库(如PubMed、Web of Science)检索确认。若需具体文章，建议结合"NIF3L1 antibody applications"或"NIF3L1 functional studies"等关键词进一步筛选。
The NIF3L1 (NGG1-interacting factor 3-like 1) antibody is a tool used to study the NIF3L1 protein, encoded by the *NIF3L1* gene in humans. This evolutionarily conserved protein is ubiquitously expressed and implicated in diverse cellular processes, including transcriptional regulation, cell cycle control, and stress response. Structurally, NIF3L1 contains a NIF3-type domain, suggesting its role in protein-protein or protein-nucleic acid interactions. While its exact molecular mechanisms remain under investigation, studies link NIF3L1 to chromatin remodeling complexes and DNA damage response pathways. It may act as a scaffold or modulator in signaling networks, influencing gene expression and cellular homeostasis.
Antibodies targeting NIF3L1 enable researchers to explore its expression patterns, subcellular localization (primarily nuclear), and interactions in model systems. These antibodies are critical for techniques like Western blotting, immunofluorescence, and immunoprecipitation. Dysregulation of NIF3L1 has been tentatively associated with cancers and neurological disorders, though functional studies are ongoing. Commercial NIF3L1 antibodies are typically validated in species like human, mouse, and rat, with applications spanning basic research and disease mechanism studies. Researchers prioritize antibodies with high specificity, often verified via knockout controls, to ensure reliability in detecting this moderately characterized protein.
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