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Rabbit Polyclonal AMDHD2 Antibody

  • 中文名: AMDHD2抗体
  • 别    名: CGI-14
货号: IPDX07837
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/2000-1/5000 Human,Mouse,Rat

产品详情

参考文献

以下是关于AMDHD2抗体的假设性参考文献示例(实际文献可能需要通过学术数据库进一步验证):

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1. **文献名称**: *"Characterization of AMDHD2 Enzymatic Activity and Its Role in Cellular Metabolism"*

**作者**: Müller, J. et al.

**摘要**: 本研究解析了AMDHD2蛋白的酰胺水解酶活性,并利用特异性抗体通过免疫印迹和免疫荧光技术证实其在细胞线粒体中的定位。实验表明AMDHD2参与核苷酸代谢通路,敲低后导致细胞增殖抑制。

2. **文献名称**: *"Development of a Polyclonal Antibody Against Human AMDHD2 for Detection in Colorectal Cancer Tissues"*

**作者**: Chen, L. et al.

**摘要**: 文章报道了一种针对人源AMDHD2的多克隆抗体的开发,验证了其特异性后应用于结直肠癌组织样本分析。结果显示AMDHD2在肿瘤组织中高表达,可能与癌症代谢重编程相关。

3. **文献名称**: *"AMDHD2 as a Novel Biomarker in Hepatocellular Carcinoma: Insights from Proteomic Profiling"*

**作者**: Tanaka, K. et al.

**摘要**: 通过蛋白质组学筛选发现AMDHD2在肝癌中异常表达,使用商业化抗体验证其表达水平与患者预后负相关,提示其作为潜在治疗靶点的可能性。

4. **文献名称**: *"Structural and Functional Analysis of AMDHD2 Using CRISPR/Cas9 and Antibody-Based Approaches"*

**作者**: Smith, R. & Wang, Y.

**摘要**: 结合CRISPR/Cas9基因编辑技术和定制抗体,研究揭示了AMDHD2在小鼠模型中的生理功能,证明其缺失会引发代谢紊乱,并影响肝脏脂质代谢。

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**注意**:以上文献为示例,实际引用时请通过PubMed、Web of Science等平台检索最新研究,并使用真实存在的文献信息。若研究较少,可尝试扩展关键词(如“AMDHD2 AND antibody”或“AMDHD2 protein expression”)或联系相关领域作者获取抗体使用详情。

背景信息

The AMDHD2 (Adenylate and Methylthiohydrolase Domain-containing Protein 2) antibody is a research tool used to study the AMDHD2 protein, which plays a role in nucleotide metabolism. AMDHD2 is a conserved enzyme involved in the methionine salvage pathway, catalyzing the hydrolysis of methylthioadenosine (MTA) and other adenine derivatives. This pathway is critical for recycling sulfur-containing metabolites and maintaining cellular homeostasis. Dysregulation of AMDHD2 has been linked to metabolic disorders and cancer progression, as altered nucleotide metabolism is a hallmark of tumorigenesis. The AMDHD2 antibody enables detection and quantification of the protein in various experimental settings, such as Western blotting, immunohistochemistry, and immunofluorescence. It aids in investigating AMDHD2's expression patterns, subcellular localization, and interactions in normal and diseased tissues. Researchers utilize this antibody to explore its potential as a biomarker or therapeutic target, particularly in oncology. Commercially available AMDHD2 antibodies are typically raised in rabbits or mice using recombinant protein fragments or synthetic peptides. Validation data, including knockout cell line controls, are essential to confirm specificity. Studies employing this antibody contribute to understanding metabolic adaptations in proliferating cells and AMDHD2's role in health and disease.

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