| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | ZMYND13 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human ANKMY1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ANKMY1抗体的3篇参考文献及其摘要内容：
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1. **文献名称**: *ANKMY1 regulates cell cycle progression and interacts with the tumor suppressor p53*
**作者**: Smith J, et al.
**摘要**: 本研究利用ANKMY1抗体通过免疫共沉淀和Western blot技术，发现ANKMY1与p53蛋白直接结合，参与DNA损伤后的细胞周期停滞调控。研究提示ANKMY1可能作为肿瘤抑制因子，在癌症中表达下调。
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2. **文献名称**: *ANKMY1 modulates the hypoxia response by stabilizing HIF-1α*
**作者**: Lee H, et al.
**摘要**: 通过免疫荧光和ChIP实验结合ANKMY1抗体，作者发现ANKMY1在低氧条件下与HIF-1α相互作用，增强其稳定性并促进血管生成相关基因表达，揭示其在肿瘤微环境中的潜在作用。
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3. **文献名称**: *Expression and prognostic significance of ANKMY1 in neuroblastoma*
**作者**: Tanaka R, et al.
**摘要**: 该研究使用ANKMY1抗体对神经母细胞瘤组织进行免疫组化分析，发现ANKMY1高表达与患者生存率正相关，提示其可作为神经发育相关癌症的预后标志物。
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**备注**：以上文献为示例，实际引用时需根据具体研究领域补充真实发表的论文(可检索PubMed或Google Scholar)。
The ANKMY1 antibody is a research tool used to detect ANKMY1 (Ankyrin Repeat and MYND Domain Containing 1), a protein encoded by the ANKMY1 gene in humans. This protein contains ankyrin repeat domains, which are known to mediate protein-protein interactions, and a MYND domain, typically involved in transcriptional regulation through chromatin remodeling. While the full functional role of ANKMY1 remains under investigation, studies suggest its potential involvement in cellular processes such as DNA damage response, cell cycle regulation, and neural development. It has been linked to interactions with proteins like DYRK1A (dual-specificity tyrosine phosphorylation-regulated kinase 1A), implicating possible roles in neurodevelopmental pathways or disorders.
ANKMY1 antibodies are primarily utilized in molecular biology and biomedical research to study the expression, localization, and functional mechanisms of ANKMY1 in various tissues and disease models. These antibodies are validated for applications such as Western blotting, immunofluorescence, and immunohistochemistry. Emerging evidence highlights ANKMY1's potential relevance in cancer biology, with altered expression observed in certain malignancies, though its exact role as an oncogene or tumor suppressor remains unclear. Commercial ANKMY1 antibodies are available from multiple suppliers, often developed using immunogens targeting specific epitopes within the protein's conserved regions. Ongoing research aims to clarify its physiological and pathological significance, particularly in contexts like neurodevelopment, genomic stability, and disease progression.
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