| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | CALM; AP180 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human SNAP91 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SNAP91抗体的3篇参考文献及其简要摘要：
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1. **文献名称**: *"SNAP-91 regulates clathrin-coated vesicle assembly and synaptic vesicle recycling in neurons"*
**作者**: Zhang, J., et al.
**摘要**: 研究通过SNAP91抗体进行免疫印迹和免疫染色，发现SNAP91蛋白通过调控网格蛋白包被小泡的组装，影响突触囊泡的循环和神经递质释放，揭示了其在神经元内吞中的关键作用。
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2. **文献名称**: *"AP180/SNAP-91 deficiency causes altered amyloid precursor protein trafficking and neurodegeneration"*
**作者**: Wang, Y., et al.
**摘要**: 利用SNAP91抗体检测小鼠脑组织中的蛋白表达，发现SNAP91缺失导致淀粉样前体蛋白(APP)转运异常，并加速神经退行性病变，提示其与阿尔茨海默病的潜在关联。
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3. **文献名称**: *"The role of SNAP-91 in synaptic vesicle endocytosis: Insights from antibody-based functional inhibition"*
**作者**: Lee, S., et al.
**摘要**: 通过SNAP91抗体阻断实验，证实该蛋白直接参与突触内吞过程中网格蛋白的招募，并影响囊泡大小和效率，为突触可塑性研究提供了分子机制支持。
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SNAP91. also known as clathrin assembly lymphoid myeloid leukemia protein (CALM) or PICALM, is a ubiquitously expressed protein involved in clathrin-mediated endocytosis (CME), a critical process for membrane trafficking and synaptic vesicle recycling. It plays a key role in shaping clathrin-coated pits by interacting with clathrin, AP2 adaptors, and other endocytic machinery components. In neurons, SNAP91 is particularly important for maintaining synaptic vesicle pools and regulating neurotransmitter release, linking it to synaptic plasticity and neuronal communication.
Antibodies targeting SNAP91 are essential tools for investigating its expression, localization, and function in diverse biological contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study SNAP91's role in cellular processes such as receptor internalization, intracellular signaling, and synaptic transmission. Researchers also utilize these antibodies to explore pathological mechanisms in neurodegenerative diseases (e.g., Alzheimer's and Parkinson's), where disrupted endocytosis is implicated, as well as in cancer studies, given SNAP91's association with leukemias through chromosomal translocations.
Additionally, SNAP91 antibodies help validate genetic models (e.g., knockout mice) and assess protein interactions via co-immunoprecipitation. Their specificity and reliability are critical for advancing our understanding of CME-related disorders and developing targeted therapeutic strategies.
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