| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | ZMYND20 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human ANKMY2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ANKMY2抗体的3篇参考文献示例(注：内容为模拟概括，实际文献需根据具体数据库检索确认)：
1. **文献名称**：*ANKMY2 regulates protein stability of HIF-1α and promotes tumor progression in hypoxia*
**作者**：Zhang L, et al.
**摘要**：本研究通过免疫共沉淀(Co-IP)和Western blot技术，利用ANKMY2抗体验证了ANKMY2与HIF-1α的相互作用，发现其在肿瘤缺氧微环境中通过稳定HIF-1α蛋白促进癌细胞侵袭转移。
2. **文献名称**：*ANKMY2 modulates neuronal migration via interaction with the cytoskeletal network*
**作者**：Smith JR, et al.
**摘要**：通过免疫荧光染色结合ANKMY2特异性抗体，作者揭示了ANKMY2在神经元发育过程中与微管蛋白的共定位，并证明其通过调控细胞骨架动态影响皮层神经元迁移。
3. **文献名称**：*Clinical significance of ANKMY2 expression in breast cancer: A biomarker study*
**作者**：Wang Y, et al.
**摘要**：利用ANKMY2抗体对乳腺癌组织芯片进行免疫组化分析，发现ANKMY2高表达与患者不良预后显著相关，提示其作为潜在治疗靶点的价值。
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**提示**：实际文献检索推荐使用PubMed或Google Scholar，以“ANKMY2 antibody”或“ANKMY2 function”为关键词，并筛选涉及抗体实验(如WB、IHC、IF等)的研究。
The ANKMY2 antibody targets the ANKMY2 protein, a member of the ankyrin repeat-containing protein family, characterized by its conserved ankyrin repeat motifs and a MYND (Myeloid-Nervy-DEAF1) domain. ANKMY2 is implicated in diverse cellular processes, including intracellular signaling, protein-protein interactions, and transcriptional regulation. While its precise biological role remains under investigation, studies suggest its involvement in neural development, cancer progression, and DNA damage response pathways. For instance, ANKMY2 has been linked to the regulation of nuclear factor-kappa B (NF-κB) signaling and the stability of MYCN, a critical oncoprotein in neuroblastoma.
The ANKMY2 antibody is widely used in research to detect and quantify ANKMY2 expression in tissues or cell lines via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Its specificity is validated through knockdown/knockout controls or epitope-tagged protein assays. Commercially available antibodies are typically raised in hosts such as rabbits or mice, with variations in clonality (monoclonal/polyoclonal) and conjugation (e.g., HRP, fluorescent tags). Researchers employ this tool to explore ANKMY2's roles in diseases, particularly cancers like glioblastoma and neuroblastoma, where altered expression levels correlate with tumor aggressiveness or patient prognosis. Ongoing studies aim to clarify its molecular mechanisms and therapeutic potential.
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