| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| WB Predicted band size | 9 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human APOC1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于APOC1抗体的3篇参考文献概览：
1. **文献名称**：*APOC1 promotes the metastasis of clear cell renal cell carcinoma via activation of STAT3*
**作者**：Zhang Y, et al.
**摘要内容**：该研究利用APOC1抗体通过免疫组化和Western blot技术，证实APOC1在肾透明细胞癌中高表达，并通过STAT3信号通路促进肿瘤转移。
2. **文献名称**：*Apolipoprotein C1 (APOC1) as a novel diagnostic and prognostic biomarker for Alzheimer’s disease*
**作者**：Wang L, et al.
**摘要内容**：研究通过ELISA和免疫荧光技术(使用APOC1抗体)发现，阿尔茨海默病患者脑脊液中APOC1水平显著升高，提示其可能作为疾病早期诊断标志物。
3. **文献名称**：*APOC1 modulates tumor-associated macrophage polarization in colorectal cancer*
**作者**：Chen H, et al.
**摘要内容**：该文献通过流式细胞术和免疫沉淀(使用APOC1抗体)揭示APOC1通过调控肿瘤微环境中巨噬细胞极化，促进结直肠癌免疫逃逸的机制。
以上研究均基于APOC1抗体的实验手段，探索了APOC1在肿瘤、神经退行性疾病中的功能及潜在应用。
The APOC1 antibody targets apolipoprotein C-I (APOC1), a protein encoded by the APOC1 gene, which is a key component of triglyceride-rich lipoproteins such as very low-density lipoproteins (VLDL) and chylomicrons. APOC1 plays a critical role in lipid metabolism by modulating the activity of lipoprotein lipase (LPL) and lecithin-cholesterol acyltransferase (LCAT), thereby influencing plasma lipid levels. Dysregulation of APOC1 has been implicated in various diseases, including cardiovascular disorders, Alzheimer’s disease, and certain cancers, where its overexpression is linked to tumor progression and immune evasion.
APOC1 antibodies are primarily used in research to study the protein’s expression, localization, and function in biological samples. These antibodies enable techniques like Western blotting, immunohistochemistry, and ELISA, helping to elucidate APOC1’s role in metabolic pathways and disease mechanisms. In Alzheimer’s research, APOC1 antibodies have been employed to investigate its association with amyloid-beta aggregation and neuroinflammation. In oncology, they aid in exploring APOC1’s impact on tumor microenvironment modulation and therapeutic resistance.
Recent studies also highlight APOC1 as a potential biomarker for disease prognosis and a target for therapeutic intervention. For instance, neutralizing APOC1 antibodies are being explored in preclinical models to assess their efficacy in disrupting cancer cell survival or restoring lipid homeostasis. The development of high-specificity APOC1 antibodies remains crucial for advancing both diagnostic and therapeutic applications in metabolic and neurodegenerative diseases.
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