Rabbit Polyclonal DNAJB1 Antibody

The DNAJB1 antibody is a valuable tool for studying the DNAJB1 protein, a member of the HSP40 (heat shock protein 40) family. DNAJB1. also known as Hsp40 homolog subfamily B member 1. functions as a co-chaperone with HSP70 to regulate protein folding, prevent aggregation, and facilitate stress response pathways. It contains a conserved J-domain critical for binding HSP70. enabling ATPase activity and substrate transfer. DNAJB1 is implicated in cellular processes like apoptosis, autophagy, and proteostasis, and its dysregulation is linked to cancers, neurodegenerative diseases (e.g., Alzheimer’s, Parkinson’s), and cardiovascular disorders. The antibody is widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to detect DNAJB1 expression levels in tissues or cells. Research applications include exploring its role in cancer progression (e.g., metastasis, drug resistance) and neuroprotection, as well as its interaction with pathogenic proteins (e.g., α-synuclein, tau). Commercial DNAJB1 antibodies are typically validated for specificity across human, mouse, and rat samples, with isoforms (cytoplasmic or mitochondrial) noted. Studies also investigate its induction under stress conditions (e.g., heat shock, oxidative stress) via HSF1-mediated transcription, highlighting its biomarker potential in disease diagnosis and therapeutic targeting.