| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | CABL1; IK3-1; CABLES; HsT2563 |
| WB Predicted band size | 68 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human CABLES1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CABLES1抗体的3篇参考文献的简要信息：
1. **文献名称**：*CABLES1. a cyclin-dependent kinase-interacting protein, is altered in human cancers*
**作者**：Sjoblom T, et al.
**摘要**：本研究通过基因组筛查发现CABLES1在结直肠癌中频繁发生表达缺失或突变，利用CABLES1抗体进行免疫组化分析，证实其表达下调与肿瘤进展相关，提示其作为潜在肿瘤抑制因子的作用。
2. **文献名称**：*CABLES1 links Wnt/β-catenin signaling to cell cycle regulation*
**作者**：Chen Y, et al.
**摘要**：文章报道CABLES1通过调控CDK3活性参与Wnt/β-catenin信号通路，使用CABLES1抗体进行免疫共沉淀实验，证明其与β-catenin和CDK3形成复合物，影响细胞周期G1/S期转换。
3. **文献名称**：*Loss of CABLES1 promotes glioblastoma invasiveness via EGFR signaling*
**作者**：Nakayama KI, et al.
**摘要**：研究通过Western blot和免疫荧光(使用CABLES1抗体)发现胶质母细胞瘤中CABLES1表达缺失导致EGFR信号异常激活，进而增强肿瘤细胞侵袭性，提示其作为治疗靶点的潜力。
(注：以上文献为虚构示例，实际引用需查询具体数据库。)
CABLES1 (Cdk5 and Abl enzyme substrate 1) is a cell cycle regulatory protein encoded by the *CABLES1* gene located on chromosome 18q11.2. It belongs to the CABLES family of cyclin-dependent kinase (CDK)-interacting proteins and contains a conserved C-terminal domain that facilitates interactions with CDKs. CABLES1 functions as a tumor suppressor by modulating CDK activity, particularly through its binding to CDK3 and CDK5. and plays a role in cell cycle arrest, apoptosis, and DNA damage response. It also interacts with p53. enhancing its transcriptional activity to regulate cell fate decisions.
CABLES1 expression is frequently downregulated in various cancers, including colorectal, ovarian, and endometrial cancers, often due to promoter hypermethylation. Loss of CABLES1 is associated with poor prognosis and chemoresistance. Antibodies targeting CABLES1 are essential tools for studying its expression, localization, and functional roles in cellular pathways. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence to investigate CABLES1's involvement in tumor suppression, cell cycle dynamics, and therapeutic responses. Commercial CABLES1 antibodies are typically validated for specificity using knockout cell lines or siRNA-mediated knockdown to ensure accurate detection in both research and diagnostic contexts.
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