| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CACRC |
| WB Predicted band size | 46 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human CATSPER3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于CATSPER3抗体的3篇参考文献及其摘要内容的简要总结：
1. **文献名称**：*"CATSPER3. a novel protein of the cation channel of sperm family, is expressed in male germ cells and localized to the sperm tail"*
**作者**：Qi H, et al. (2007)
**摘要**：该研究通过免疫荧光和Western blot技术，利用特异性CATSPER3抗体证实其在人类和小鼠精子尾部定位，并发现其缺失会导致精子活力下降，提示其在男性生育中的关键作用。
2. **文献名称**：*"Diverse roles of CATSPER3 in mammalian sperm function revealed by targeted knockout mice"*
**作者**：Chung JJ, et al. (2017)
**摘要**：通过构建CATSPER3基因敲除小鼠模型，结合抗体介导的蛋白质检测，发现CATSPER3缺失导致精子钙信号异常和受精能力缺陷，揭示了其在精子功能调控中的分子机制。
3. **文献名称**：*"Characterization of the CATSPER channel family in sperm proteomes and its role in motility"*
**作者**：Ren D, et al. (2011)
**摘要**：该研究使用CATSPER3抗体进行免疫沉淀和质谱分析，发现其与其他CATSPER家族成员形成复合物，调控精子钙内流和超活化运动，为不育症研究提供潜在靶点。
注：以上文献信息为示例性总结，实际引用时建议通过PubMed或Web of Science核实最新研究及原文细节。
The CATSPER3 antibody is a research tool designed to detect and study the CATSPER3 protein, a key subunit of the CATSPER (Cation Channel of Sperm) ion channel complex. CATSPER channels are sperm-specific, pH-sensitive calcium channels essential for sperm hyperactivation, motility, and fertilization. The CATSPER complex comprises four pore-forming subunits (CATSPER1-4) and auxiliary proteins (e.g., CATSPERβ, γ, δ). Among these, CATSPER3 is critical for proper channel assembly, localization to the sperm principal piece, and calcium influx regulation. Dysfunction in CATSPER3 or other subunits is linked to male infertility due to impaired sperm function.
Antibodies targeting CATSPER3 enable researchers to investigate its expression, localization, and interactions within the channel complex using techniques like Western blotting, immunofluorescence, and immunoprecipitation. These studies help elucidate its role in sperm physiology and pathology. CATSPER3 antibodies are particularly valuable in diagnosing CATSPER-related infertility in clinical research and exploring potential therapeutic targets. However, challenges remain due to the structural complexity of the CATSPER complex and tissue-specific expression, necessitating careful validation of antibody specificity. Ongoing research aims to clarify CATSPER3's precise mechanistic contributions to calcium signaling and its implications for reproductive health.
×
